{"doi":"10.3109/10428199109068136","title":"Augmentation of the Susceptibility of Human Leukemia to Lymphokine-Activated Killer (LAK) Cells by Exposure of the Leukemic Target Cells to Cytotoxic Drugs in Vitro and in Vivo","abstract":null,"journal":"Leukemia & Lymphoma","year":1991,"id":658275,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1718392,"name":"Wolf-Dieter Ludwig","orcid":null,"position":1,"is_corresponding":false},{"id":1718393,"name":"Eckhard Thiel","orcid":null,"position":2,"is_corresponding":false},{"id":1718391,"name":"Johannes V. Teichmann","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Augmentation of the Susceptibility of Human Leukemia to Lymphokine-Activated Killer (LAK) Cells by Exposure of the Leukemic Target Cells to Cytotoxic Drugs in Vitro and in Vivo","abstract":"Experimental studies have shown that interleukin-2-induced lymphokine-activated killer (LAK) cells are able to lyse fresh noncultured leukemia cells and that human leukemia cells have a distinct susceptibility to LAK-cell-mediated cytolysis. Cytolysis is considerably lower with fresh noncultured leukemia cells than with the leukemia cell lines K562 and Daudi. For therapeutic considerations it would be desirable to achieve as much cytolysis as possible. The current study revealed that incubating leukemia cells with cytotoxic drugs in vitro significantly augments their susceptibility to the lytic effect of LAK cells and, more importantly that exposing leukemia cells to anticancer agents in vivo during induction chemotherapy also increases their sensitivity to LAK-cell-mediated cytolysis. These results support a possible benefit from combining chemotherapy with immunotherapeutic approaches in leukemia treatment.","is_dataset_classified":null,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"27467849","pmcid":null,"openalex_id":"https://openalex.org/W2157408192","authors":[],"funders":[],"total_grants":0,"fwci":0.1376,"citation_percentile":0.46532403,"influential_citations":0,"citation_trend":[],"oa_status":"closed","license":null,"oa_locations":[{"url":"http://www.tandfonline.com/doi/pdf/10.3109/10428199109068136","host_type":"publisher"},{"url":"https://doi.org/10.3109/10428199109068136","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/27467849","host_type":"repository"}],"fields_of_study":["Immune Cell Function and Interaction","Hematopoietic Stem Cell Transplantation","Acute Myeloid Leukemia Research"],"mesh_terms":[],"keywords":["Cytolysis","Lymphokine-activated killer cell","K562 cells","Leukemia","Cytotoxic T cell","Lymphokine","Immunology","Cancer research","In vivo","Biology","Myeloid leukemia","In vitro","Interleukin 12","Immune system","Biochemistry","Interleukin-2","Cytotoxic Drugs","Lymphokine-activated Killer (Lak) Cells","Augmentation Of Susceptibility To Lak Cells","Susceptibility Of Human Leukemia To Lak Cells"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-12T03:45:03.461200Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}