{"doi":"10.3109/09553002.2011.624153","title":"Interaction between total body gamma-irradiation and choline deficiency triggers immediate modulation of choline and choline-containing moieties","abstract":null,"journal":"International Journal of Radiation Biology","year":2011,"id":606097,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1555752,"name":"Binita Kislay","orcid":null,"position":1,"is_corresponding":false},{"id":1555753,"name":"Thomas Paul Asir Devasagayam","orcid":null,"position":2,"is_corresponding":false},{"id":1555751,"name":"Vipen Batra","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Interaction between total body gamma-irradiation and choline deficiency triggers immediate modulation of choline and choline-containing moieties","abstract":"PURPOSE: The objective of this study was to examine the effect of 60Co-gamma (γ) radiation on acute phase modulation, if any, of choline and choline-containing moieties in choline-deficient subjects. Corresponding results could provide information that might be useful in the management of adverse effects of γ-radiation. MATERIALS AND METHODS: Male Swiss mice maintained on a choline-sufficient diet (CSD) and choline-free diet (CFD) based on AIN-93M formula, were subjected to whole body γ-irradiation (2-6 Gy). Liver, serum and brain samples from each group were then tested for: (i) Alterations in choline and choline-containing moieties such as phosphatidylcholine (PC) and sphingomyeline (SM); and (ii) modulation of choline profile modulating enzymes such as phospholipase D (PLD) and total sphingomyelinase (t-SMase). Liver and brain samples were also subjected to histo-pathological examinations. RESULTS: No significant changes were observed in folate, choline, choline-containing moieties and choline-modulating enzymes in choline-sufficient mice. In contrast, interaction between cytotoxic effects of γ-radiation and choline deficiency modulated choline and choline-containing moieties. Feeding CFD reduced hepatic concentrations of choline, PC and SM whereas PLD and t-SMase activities were significantly raised. The decrease in liver choline and choline-containing moieties was accompanied by an increase in blood choline concentration. Despite choline deficiency, the level of choline and acetylcholine synthesizing enzyme choline acetyltransfease (ChAT) significantly increased in the brain. CONCLUSIONS: We propose that choline deprivation and γ-radiation interact to modulate choline reserves of hepatic tissue, which might release choline to blood. Our studies also clearly showed that interaction between choline deficiency and γ-radiation might substantially enhance liver adipogenesis.","is_dataset_classified":null,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21923302","pmcid":null,"openalex_id":"https://openalex.org/W1975783069","authors":[],"funders":[],"total_grants":0,"fwci":0.199,"citation_percentile":0.65754691,"influential_citations":0,"citation_trend":[{"year":2014,"count":1},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2022,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://www.tandfonline.com/doi/pdf/10.3109/09553002.2011.624153","host_type":"publisher"},{"url":"https://doi.org/10.3109/09553002.2011.624153","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21923302","host_type":"repository"}],"fields_of_study":["Neurological Disorders and Treatments","Folate and B Vitamins Research","Advanced MRI Techniques and Applications","Adipogenesis","Animals","Brain","Choline","Choline Deficiency","Choline O-Acetyltransferase","Disease Models, Animal","Gamma Rays","Liver","Male","Mice","Phosphatidylcholines","Phospholipase D","Sphingomyelin Phosphodiesterase","Whole-Body Irradiation"],"mesh_terms":["Animals","Brain","Choline","Choline O-Acetyltransferase","Choline Deficiency","Disease Models, Animal","Gamma Rays","Liver","Male","Phosphatidylcholines","Phospholipase D","Sphingomyelin Phosphodiesterase","Whole-Body Irradiation","Adipogenesis","Mice"],"keywords":["Choline","Choline kinase","Phosphatidylcholine","Phosphocholine","Choline oxidase","Chemistry","Acetylcholine","Internal medicine","Endocrinology","Biochemistry","Enzyme","Biology","Medicine","Phospholipid","Acetylcholinesterase","Membrane"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T03:53:04.507160Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}