{"doi":"10.3109/03602532.2012.748793","title":"Nuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liver","abstract":null,"journal":"Drug Metabolism Reviews","year":2013,"id":590412,"datarank":3.3898629732771908,"base_score":4.430816798843313,"endowment":4.430816798843313,"self_citation_contribution":0.6646225198264971,"citation_network_contribution":2.7252404534506938,"self_endowment_contribution":0.6646225198264971,"citer_contribution":2.7252404534506938,"corpus_percentile":null,"corpus_rank":null,"citation_count":83,"citer_count":79,"citers_with_citation_signal":72,"citers_with_endowment":72,"datacite_reuse_total":2,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1510635,"name":"Sarah Woody","orcid":null,"position":1,"is_corresponding":false},{"id":1510636,"name":"Mengxi Sun","orcid":null,"position":2,"is_corresponding":false},{"id":347321,"name":"Wenqi Cui","orcid":"0000-0003-2022-6050","position":3,"is_corresponding":false},{"id":412003,"name":"Jeff L. Staudinger","orcid":"0000-0002-1081-269X","position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Nuclear-receptor–mediated regulation of drug– and bile-acid–transporter proteins in gut and liver","abstract":"Adverse drug events (ADEs) are a common cause of patient morbidity and mortality and are classically thought to result, in part, from variation in expression and activity of hepatic enzymes of drug metabolism. It is now known that alterations in the expression of genes that encode drug- and bile-acid-transporter proteins in both the gut and liver play a previously unrecognized role in determining patient drug response and eventual clinical outcome. Four nuclear receptor (NR) superfamily members, including pregnane X receptor (PXR, NR1I2), constitutive androstane receptor (NR1I3), farnesoid X receptor (NR1H4), and vitamin D receptor (NR1I1), play pivotal roles in drug- and bile-acid-activated programs of gene expression to coordinately regulate drug- and bile-acid transport activity in the intestine and liver. This review focuses on the NR-mediated gene activation of drug and bile-acid transporters in these tissues as well as the possible underlying molecular mechanisms.","is_dataset_classified":null,"base_score":4.430816798843313,"endowment":4.430816798843313,"datacite_reuse_total":2,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"23330541","pmcid":"PMC4557796","openalex_id":"https://openalex.org/W2067961925","authors":[],"funders":[{"funder_name":"NIDDK NIH HHS","grant_id":"R01 DK090558","title":null}],"total_grants":1,"fwci":3.3228,"citation_percentile":0.93293838,"influential_citations":0,"citation_trend":[{"year":2013,"count":2},{"year":2014,"count":3},{"year":2015,"count":7},{"year":2016,"count":11},{"year":2017,"count":8},{"year":2018,"count":8},{"year":2019,"count":7},{"year":2020,"count":9},{"year":2021,"count":4},{"year":2022,"count":9},{"year":2023,"count":3},{"year":2024,"count":4},{"year":2025,"count":6},{"year":2026,"count":2}],"oa_status":"green","license":"other-oa","oa_locations":[{"url":"http://hdl.handle.net/1808/24466","host_type":"repository"},{"url":"http://hdl.handle.net/1808/24466","host_type":"repository"},{"url":"http://www.tandfonline.com/doi/pdf/10.3109/03602532.2012.748793","host_type":"publisher"},{"url":"https://doi.org/10.3109/03602532.2012.748793","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/23330541","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/4557796","host_type":"repository"}],"fields_of_study":["Drug Transport and Resistance Mechanisms","Pharmacological Effects and Toxicity Studies","Pharmacogenetics and Drug Metabolism"],"mesh_terms":["Constitutive Androstane Receptor","Animals","Bile Acids and Salts","Biological Transport","Carrier Proteins","Humans","Liver","Membrane Glycoproteins","Inactivation, Metabolic","Receptors, Cytoplasmic and Nuclear","Gastrointestinal Tract"],"keywords":["Pregnane X receptor","Constitutive androstane receptor","Farnesoid X receptor","Nuclear receptor","G protein-coupled bile acid receptor","Bile acid","Drug metabolism","CYP8B1","Calcitriol receptor","Drug","Liver receptor homolog-1","Biology","Transporter","Cholesterol 7 alpha-hydroxylase","Receptor","Liver X receptor","Chenodeoxycholic acid","Hepatocyte nuclear factor 4","Pharmacology","Biochemistry","Gene","Transcription factor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[{"doi":"10.6084/m9.figshare.21184245.v1","title":"Additional file 1 of Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport","publisher":"figshare","resource_type":"JournalArticle"},{"doi":"10.6084/m9.figshare.21184245","title":"Additional file 1 of Nuclear receptor ligand screening in an iPSC-derived in vitro blood–brain barrier model identifies new contributors to leptin transport","publisher":"figshare","resource_type":"JournalArticle"}],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-24T20:20:00.073254Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}