{"doi":"10.31083/j.jmcm.2020.03.006","title":"ATM is necessary for IGF-1R expression in the murine mammary gland","abstract":"Ataxia-telangiectasia mutated is a protein kinase that is critical for the maintenance of genomic stability and proper cellular response to redox imbalance. Previous studies indicate that ataxia-telangiectasia mutated is also required for expression of the insulin-like growth factor-1 receptor in human fibroblasts. As insulin-like growth factor-1 receptor is critical in mammary gland development, we sought to determine the relationship between ataxia-telangiectasia mutated and insulin-like growth factor-1 receptor using mouse as a model system. Knockdown of ataxia-telangiectasia mutated in cultured mouse mammary epithelial cells resulted in a significant reduction in insulin-like growth factor-1 receptor mRNA levels. Using a conditional knockout mouse model, we observed that loss of ataxia-telangiectasia mutated resulted in a severe decrease in both insulin-like growth factor-1 receptor mRNA and protein expression. These results support the observation that insulin-like growth factor-1 receptor expression is ataxia-telangiectasia mutated -dependent in the mammary epithelium, and given the critical role that insulin-like growth factor-1 receptor plays in mammary gland development, suggests that ataxia-telangiectasia mutated may be critical in the development of this organ as well.","journal":"Journal of Molecular and Clinical Medicine","year":2020,"id":131821,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9577,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":586092,"name":"Lisa Dyer","orcid":"0000-0002-1863-0516","position":1,"is_corresponding":false},{"id":485238,"name":"Kevin D. Brown","orcid":"0000-0002-5709-8702","position":0,"is_corresponding":true}],"reference_count":41,"raw_metadata":null,"created_at":"2026-07-18T23:16:03.875886Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}