{"doi":"10.31083/j.jin2304084","title":"Effects of Unilateral High Frequency Stimulation of the Subthalamic Nucleus on Risk-avoidant Behavior in a Partial 6-hydroxydopamine Model of Parkinson's Disease","abstract":"BACKGROUND: Deep brain stimulation (DBS) of the subthalamic nucleus (STN) is a well-established treatment for the motor symptoms of Parkinson's disease (PD). While PD is primarily characterized by motor symptoms such as tremor, rigidity, and bradykinesia, it also involves a range of non-motor symptoms, and anxiety is one of the most common. The relationship between PD and anxiety is complex and can be a result of both pathological neural changes and the psychological and emotional impacts of living with a chronic progressive condition. Managing anxiety in PD is critical for improving the patients' quality of life. However, patients undergoing STN DBS can occasionally experience increased anxiety. METHODS: This study investigates changes in risk-avoidant behavior following STN DBS in a pre-motor animal model of PD under chronic and acute unilateral high frequency stimulation. RESULTS: No significant changes in risk-avoidant behaviors were observed in rats who underwent STN DBS compared with sham stimulation controls. Chronic stimulation prevented sensitization in the elevated zero maze. CONCLUSIONS: These results suggest that unilateral stimulation of the STN may have minimal effects on risk-avoidant behaviors in PD. However, additional research is required to fully understand the mechanisms responsible for changes in anxiety during STN DBS for PD.","journal":"Journal of Integrative Neuroscience","year":2024,"id":483271,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9623,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1116780,"name":"Anders J. Asp","orcid":null,"position":1,"is_corresponding":false},{"id":658973,"name":"Leena Pramanik","orcid":"0000-0003-1533-5017","position":2,"is_corresponding":false},{"id":1324467,"name":"Aarushi A. Mukerjee","orcid":null,"position":3,"is_corresponding":false},{"id":1120542,"name":"Carter B. Mulder","orcid":null,"position":4,"is_corresponding":false},{"id":1324468,"name":"Wendy D. Lujan","orcid":null,"position":5,"is_corresponding":false},{"id":1308754,"name":"Jodi L. Silvernail","orcid":null,"position":6,"is_corresponding":false},{"id":307619,"name":"Su-Youne Chang","orcid":"0000-0001-8373-8921","position":7,"is_corresponding":false},{"id":732664,"name":"Suelen L. Boschen","orcid":"0000-0002-7694-920X","position":8,"is_corresponding":false},{"id":478606,"name":"J. Luis Luján","orcid":"0000-0003-3496-3932","position":9,"is_corresponding":false},{"id":1324466,"name":"Sydney G. Hillan","orcid":null,"position":0,"is_corresponding":true}],"reference_count":56,"raw_metadata":null,"created_at":"2026-07-19T02:07:22.248464Z","pmid":"38682230","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}