{"doi":"10.31083/j.fbl2803059","title":"The Role of Glutathione in Prevention of COVID-19 Immunothrombosis: A Review","abstract":"Immunothrombosis has emerged as a dominant pathological process exacerbating morbidity and mortality in acute- and long-COVID-19 infections. The hypercoagulable state is due in part to immune system dysregulation, inflammation and endothelial cell damage, as well as a reduction in defense systems. One defense mechanism in particular is glutathione (GSH), a ubiquitously found antioxidant. Evidence suggests that reduction in GSH increases viral replication, pro-inflammatory cytokine release, and thrombosis, as well as decreases macrophage-mediated fibrin removal. The collection of adverse effects as a result of GSH depletion in states like COVID-19 suggest that GSH depletion is a dominant mechanism of immunothrombosis cascade. We aim to review the current literature on the influence of GSH on COVID-19 immunothrombosis pathogenesis, as well as the beneficial effects of GSH as a novel therapeutic for acute- and long-COVID-19.","journal":"Frontiers in Bioscience-Landmark","year":2023,"id":336067,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9454,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1067025,"name":"Nghia Le","orcid":null,"position":1,"is_corresponding":false},{"id":1067026,"name":"Mercedeh Mirhosseini","orcid":null,"position":2,"is_corresponding":false},{"id":1035465,"name":"Cheldon Ann Alcantara","orcid":null,"position":3,"is_corresponding":false},{"id":1067027,"name":"Aamna Asif","orcid":null,"position":4,"is_corresponding":false},{"id":1066466,"name":"Anabel Goulding","orcid":"0000-0002-5718-3106","position":5,"is_corresponding":false},{"id":1067028,"name":"Shafi Muneer","orcid":null,"position":6,"is_corresponding":false},{"id":1066467,"name":"Manpreet Singh","orcid":"0000-0003-2846-0597","position":7,"is_corresponding":false},{"id":1067029,"name":"Jeremiah Robison","orcid":null,"position":8,"is_corresponding":false},{"id":1067030,"name":"Frederick R. Guilford","orcid":null,"position":9,"is_corresponding":false},{"id":239632,"name":"Vishwanath Venketaraman","orcid":"0000-0002-2586-1160","position":10,"is_corresponding":false},{"id":1035024,"name":"Ira Glassman","orcid":"0000-0001-5651-6282","position":0,"is_corresponding":true}],"reference_count":115,"raw_metadata":null,"created_at":"2026-07-19T01:10:17.243221Z","pmid":"37005767","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}