{"doi":"10.31038/jmg.2020324","title":"https://researchopenworld.com/genetics-of-hidradenitis-suppurativa/#","abstract":"HS lesion counts are increased with low serum zinc and vitamin D levels. Supplementation of zinc, vitamin D, vitamin B12, or exclusion of dairy or brewer's yeast reduced lesion resolution. Bariatric surgery often causes weight loss which may lead to HS improvement but often results in more severe malnutrition that worsens or even leads to new HS onset post bariatric surgery The complement (C) system was found to be significantly down-regulated in the HS skin and blood transcriptomes and the HS blood proteome 81 . Porphyromonas species, which are able cleave inactive C5 into C5a, have been identified in the HS microbiome. C5a levels in serum and tissue correlate with disease activity and degree of neutrophilic infiltrates in HS, suggesting that complement inhibition is a promising and potential therapeutic target for HS HS lesions showed 83% bacterial culture anaerobes compred to 53% of control samples, and milleri group streptococci and actinomycetes in 33% and 26% of cases, respectively Microarray analysis demonstrated that HS lesional skin samples had significantly decreased expression of enzymes involved in generating ceramide and sphingomyelin, increased expression of enzymes that catabolize ceramide to sphingosine, and increased expression of enzymes involved in converting ceramide to galactosylceramide and gangliosides, which suggests that sphingolipid metabolism is altered in HS lesional skin compared with normal skin In HS patients, the serum and HS skin lension levels of chitinase-3-like protein 1 (YKL-40) were significantly elevated, suggesting that YKL-40 may be one of the biomarkers of HS","journal":null,"year":2020,"id":114211,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.96,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":81,"raw_metadata":null,"created_at":"2026-07-18T23:13:29.674622Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}