{"doi":"10.2989/17280583.2024.2387632","title":"Participant acceptability and clinician satisfaction of cognitive behavioural therapy and medication management algorithm compared with enhanced standard care for treatment of depression among youth with HIV","abstract":"Background: Primary results of the International Maternal Pediatric Adolescent AIDS Clinical Trials Network (IMPAACT) 2002 trial showed that cognitive behavioural therapy (CBT) and medication management algorithm (MMA) (COMB-R) significantly improved depression in youth with HIV (YWH) compared with enhanced standard care (ESC). Acceptability and satisfaction were examined among study participants and clinicians.Method: Between March 2017 and March 2019, 13 U.S. sites enrolled YWH, aged 12–24, diagnosed with nonpsychotic depression. Sites were randomised to either COMB-R (CBT by a therapist and licensed prescriber) or ESC (standard psychotherapy and medication management). After the intervention (week 24), participants, prescribers, and therapists rated acceptability and satisfaction. We compared site-level means using Wilcoxon tests.Results: Both COMB-R (n = 69) and ESC (n = 71) participants had a mean age of 21.4 years, with 53% female, and 54% having acquired HIV perinatally. Baseline age, sex, depression levels, RNA viral load, and CD4 count were comparable between arms. The distribution of site-level mean participant acceptability was greater in COMB-R compared with ESC (p = 0.04). The distribution of site-level mean prescriber satisfaction was greater in COMB-R (p = 0.01). The was no evidence that the site-level mean therapist satisfaction did not differ between arms (p = 0.52).Discussion: Acceptability and satisfaction for participants and licensed prescribers were higher at COMB-R sites compared with standard of care, indicating that this tailored, manual-guided, collaborative, measured care intervention was less burdensome in terms of the number of visits. Patient and medication provider satisfaction rates were higher than standard of care.Conclusion: While these results support the use of CBT and MMA in treating depression among YWH, further research is required to determine generalisability.","journal":"Journal of Child and Adolescent Mental Health","year":2024,"id":477971,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9477,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":484192,"name":"Kristin Baltrusaitis","orcid":"0000-0003-2090-9513","position":1,"is_corresponding":false},{"id":731260,"name":"Betsy D. Kennard","orcid":"0000-0003-2376-4348","position":2,"is_corresponding":false},{"id":731261,"name":"Graham J. Emslie","orcid":"0000-0003-1851-4328","position":3,"is_corresponding":false},{"id":627342,"name":"Chelsea Krotje","orcid":null,"position":4,"is_corresponding":false},{"id":327309,"name":"Kevin Knowles","orcid":null,"position":5,"is_corresponding":false},{"id":1215376,"name":"Sarah Buisson","orcid":null,"position":6,"is_corresponding":false},{"id":1316870,"name":"Lauren Bergam","orcid":null,"position":7,"is_corresponding":false},{"id":346914,"name":"Jaime G. Deville","orcid":"0000-0002-7523-0658","position":8,"is_corresponding":false},{"id":208668,"name":"Susan L. Gillespie","orcid":null,"position":9,"is_corresponding":false},{"id":1316871,"name":"Melissa Shikora","orcid":null,"position":10,"is_corresponding":false},{"id":593422,"name":"Ellen Townley","orcid":"0009-0007-8969-8554","position":11,"is_corresponding":false},{"id":194219,"name":"David E. Shapiro","orcid":null,"position":12,"is_corresponding":false},{"id":425970,"name":"Larry K. Brown","orcid":"0000-0002-4895-7034","position":13,"is_corresponding":false},{"id":346912,"name":"Emily Barr","orcid":"0000-0002-3578-3389","position":0,"is_corresponding":true}],"reference_count":37,"raw_metadata":null,"created_at":"2026-07-19T02:06:42.155024Z","pmid":"39550758","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}