{"doi":"10.29011/2575-8241.001313","title":"Gastrointestinal Manifestations of Hypermobile Ehlers-Danlos Syndrome and Dietary Approaches Related to Their Management","abstract":"Abstract Although hypermobile Ehlers-Danlos Syndrome and hypermobility spectrum disorders are best known for musculoskeletal manifestations such as tendon ruptures, tendonitis, osteoarthritis, and chronic joint pain, other comorbidities are common in these conditions, including gastrointestinal dysfunction. Gastrointestinal symptoms experienced by those with hypermobile EhlersDanlos Syndrome and hypermobility spectrum disorders are primarily functional and nonlife threatening, but negatively impact quality of life. Some symptoms associated with these conditions include bloating, reflux, and abdominal discomfort which can potentially be managed using dietary approaches. Limited evidence suggests that protein and vitamin D intakes are lower in those with hypermobile Ehlers-Danlos Syndrome and hypermobility spectrum disorders, and these nutrients are well known for playing critical roles in musculoskeletal system making them points of emphasis for researchers and clinicians involved with hypermobile Ehlers-Danlos Syndrome and hypermobility spectrum disorders. More research is needed to establish the best dietary approaches to manage the gastrointestinal symptoms related to these conditions and to determine if there are other shortfall nutrients.","journal":"Journal of Orthopedic Research and Therapy","year":2023,"id":385256,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9546,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1152984,"name":"Anne Bodensteiner","orcid":"0009-0008-5314-6595","position":1,"is_corresponding":false},{"id":783840,"name":"Nathaniel Johnson","orcid":"0000-0002-1577-3167","position":2,"is_corresponding":false},{"id":1153360,"name":"Lauren Steiner","orcid":null,"position":0,"is_corresponding":true}],"reference_count":24,"raw_metadata":null,"created_at":"2026-07-19T01:17:48.629718Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}