{"doi":"10.2741/s100","title":"Kappa2 opioid receptor subtype binding requires the presence of the DOR-1 gene","abstract":null,"journal":"Frontiers in Bioscience","year":2010,"id":686297,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1792990,"name":"John E Pintar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Kappa2 opioid receptor subtype binding requires the presence of the DOR-1 gene","abstract":"Over the past several years substantial evidence has documented that opioid receptor homo- and heterodimers form in cell lines expressing one or more of the opioid receptors. We used opioid receptor knockout mice to determine whether in vivo pharmacological characteristics of kappa1 and kappa2 opioid receptors changed following knockout of specific opioid receptors. Using displacement of the general opioid ligand diprenorphine, we observed that occupancy or knockout of the DOR-1 gene increases the binding density of kappa1 receptors and eliminates kappa2 receptors in crude membrane preparations while the total density of kappa opioid binding sites is unchanged. Further, the analgesic potency of U69,593 in cumulative dose response curves is enhanced in mice lacking the DOR-1 gene. These results demonstrate that the DOR-1 gene is required for the expression of the kappa2 opioid receptor subtype and are consistent with the possibility that a KOR-1/DOR-1 heterodimer mediates kappa2 pharmacology.","is_dataset_classified":null,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"20036983","pmcid":null,"openalex_id":"https://openalex.org/W164060227","authors":[],"funders":[{"funder_name":"NIDA NIH HHS","grant_id":"DA-15237","title":null},{"funder_name":"NIA NIH HHS","grant_id":"T32 MG/AG-19957","title":null},{"funder_name":"NIDA NIH HHS","grant_id":"F32 DA-14755","title":null},{"funder_name":"National Institutes of Health","grant_id":"1F32DA014755-01","title":"Functional Characterization of the DOR-1 Knockout Mouse"}],"total_grants":4,"fwci":0.5789,"citation_percentile":0.58368479,"influential_citations":0,"citation_trend":[{"year":2012,"count":1},{"year":2013,"count":1},{"year":2014,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.imrpress.com/journal/FBS/2/2/10.2741/S100/pdf","host_type":"journal"},{"url":"https://www.imrpress.com/journal/FBS/2/2/10.2741/S100/pdf","host_type":"publisher"},{"url":"https://doi.org/10.2741/s100","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/20036983","host_type":"repository"},{"url":"https://dx.doi.org/10.2741/s100","host_type":""}],"fields_of_study":["Neuropeptides and Animal Physiology","Receptor Mechanisms and Signaling","Pharmacological Receptor Mechanisms and Effects","0301 basic medicine","0303 health sciences","03 medical and health sciences","Analysis of Variance","Animals","Benzeneacetamides","Diprenorphine","Dose-Response Relationship, Drug","Enkephalin, D-Penicillamine (2,5)-","Mice","Mice, Knockout","Pain Measurement","Protein Binding","Pyrrolidines","Receptors, Opioid, delta","Receptors, Opioid, kappa","Regression Analysis"],"mesh_terms":["Analysis of Variance","Animals","Diprenorphine","Dose-Response Relationship, Drug","Pain Measurement","Protein Binding","Pyrrolidines","Regression Analysis","Receptors, Opioid, delta","Receptors, Opioid, kappa","Mice, Knockout","Enkephalin, D-Penicillamine (2,5)-","Benzeneacetamides","Mice"],"keywords":["Diprenorphine","Receptor","Opioid","Opioid receptor","Knockout mouse","Pharmacology","Chemistry","κ-opioid receptor","Gene knockout","Biology","Gene","Biochemistry","Mice, Knockout","Analysis of Variance","Pyrrolidines","Dose-Response Relationship, Drug","Receptors, Opioid, kappa","Benzeneacetamides","Mice","Receptors, Opioid, delta","Animals","Regression Analysis","Enkephalin, D-Penicillamine (2,5)-","Pain Measurement","Protein Binding"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-18T19:06:38.821415Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}