{"doi":"10.26904/rf-152-6257908952","title":"Tip60: A realistic target to treat Alzheimer’s disease?","abstract":"Alzheimer's disease (AD) is an incurable disease that affects cognitive function.The greatest risk factor for developing AD is ageing -most people with Alzheimer's are over 65 years old.AD is a progressive condition that affects parts of the brain that control thought, memory, and language.The main features of Alzheimer's pathology include the loss of connections between neurons and protein aggregates called amyloid plaques, which are found in the patient's brain.Over the years, extensive research on AD has increased our understanding of the pathology of this devastating condition, although insights on the cause of the disease and treatment options lag behind.One important finding is that the protein-making machinery goes awry in AD.Examining this further, a team of researchers at Drexel University and the University of Pennsylvania, USA, uncovered the role of an enzyme called Tip60.Tip60 normally plays a significant role in producing the right kind of proteins for a healthy brain, but it malfunctions in the brain of Alzheimer's patients.","journal":"Research Features","year":2024,"id":495410,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9575,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":313591,"name":"Felice Elefant","orcid":"0000-0002-9709-3690","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:09:19.627139Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}