{"doi":"10.26599/nr.2025.94907707","title":"Immunoengineering strategies using nanoparticles for obesity treatment","abstract":"Obesity has emerged as a global epidemic, posing severe challenges to public health and contributing to various complications, including metabolic disorders, cardiovascular disease, and type 2 diabetes. This review provides a comprehensive overview of obesity, its associated comorbidities, and the limitations of conventional treatments. We explore the complex relationship between obesity-induced inflammation, immune dysregulation, and the pivotal role of adipose tissue macrophages (ATMs). Chronic low-grade inflammation in adipose tissues (AT) is a key driver of insulin resistance and metabolic dysfunction. As ATs expand, they undergo significant changes, including increased immune cell infiltration, particularly macrophages (MΦs), which shift from an anti-inflammatory towards a pro-inflammatory phenotype. This review aims to advance the understanding of immunomodulatory strategies by examining MΦ polarization and AT browning as promising therapeutic approaches. We focus on nanoparticles (NPs)-based strategies for immunomodulation, highlighting innovative engineering approaches designed to target the inflammatory pathways underlying obesity. By addressing these mechanisms, this review provides valuable insights into mitigating obesity-associated inflammation and related metabolic disorders, paving the way for novel therapeutic strategies in the fight against the global obesity epidemic.","journal":"Nano Research","year":2025,"id":532569,"datarank":0.24141568686511508,"base_score":1.6094379124341003,"endowment":1.6094379124341003,"self_citation_contribution":0.24141568686511508,"citation_network_contribution":0.0,"self_endowment_contribution":0.24141568686511508,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":4,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9551,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1365925,"name":"Narges Zargar Balajam","orcid":null,"position":1,"is_corresponding":false},{"id":1414125,"name":"Bahareh Hosseinpour","orcid":null,"position":2,"is_corresponding":false},{"id":1025877,"name":"Claire Buttles","orcid":"0009-0003-6008-2669","position":3,"is_corresponding":false},{"id":994450,"name":"Qiang Huang","orcid":"0000-0002-2052-1140","position":4,"is_corresponding":false},{"id":1030879,"name":"Yixuan Huang","orcid":"0000-0003-2162-4544","position":5,"is_corresponding":false},{"id":1025876,"name":"Amir Ahari","orcid":"0000-0002-0742-5576","position":6,"is_corresponding":false},{"id":1413699,"name":"Neda Farhadi","orcid":"0000-0002-5276-1472","position":7,"is_corresponding":false},{"id":705782,"name":"Saya Davani","orcid":null,"position":8,"is_corresponding":false},{"id":1026349,"name":"Safoora Khosravi","orcid":null,"position":9,"is_corresponding":false},{"id":1414126,"name":"Bahareh Mirmashhouri","orcid":"0009-0008-6781-5024","position":10,"is_corresponding":false},{"id":1025878,"name":"Negar Hosseinzadeh Kouchehbaghi","orcid":"0000-0002-0290-0411","position":11,"is_corresponding":false},{"id":1361396,"name":"Rohan R Sampath","orcid":"0009-0009-2419-0842","position":12,"is_corresponding":false},{"id":871147,"name":"Mohsen Akbari","orcid":"0000-0003-2902-6557","position":13,"is_corresponding":false},{"id":642200,"name":"Vadim Jucaud","orcid":"0000-0003-0385-2623","position":14,"is_corresponding":false},{"id":853037,"name":"Heemin Kang","orcid":"0000-0003-1359-2810","position":15,"is_corresponding":false},{"id":230339,"name":"Ali Khademhosseini","orcid":"0000-0002-2692-1524","position":16,"is_corresponding":false},{"id":260785,"name":"Ryan M. Pearson","orcid":"0000-0002-7857-0973","position":17,"is_corresponding":false},{"id":249122,"name":"Alireza Hassani Najafabadi","orcid":"0000-0002-8215-4374","position":18,"is_corresponding":false},{"id":958855,"name":"Neda Mohaghegh","orcid":"0000-0002-2796-4315","position":0,"is_corresponding":true}],"reference_count":127,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:51:23.237536Z","pmid":"41602577","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}