{"doi":"10.26599/fshw.2024.9250121","title":"Rosmarinic acid regulates lipid accumulation through lipid metabolism and anti-inflammatory","abstract":null,"journal":"Food Science and Human Wellness","year":2025,"id":608057,"datarank":0.20794415416798362,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"self_citation_contribution":0.20794415416798362,"citation_network_contribution":0.0,"self_endowment_contribution":0.20794415416798362,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1561525,"name":"Zhuobin Li","orcid":null,"position":1,"is_corresponding":false},{"id":1344757,"name":"Yun Chen","orcid":"0000-0002-4118-362X","position":2,"is_corresponding":false},{"id":1561527,"name":"Jingrui Luo","orcid":null,"position":3,"is_corresponding":false},{"id":733086,"name":"Guo Liu","orcid":null,"position":4,"is_corresponding":false},{"id":125619,"name":"Chi-Tang Ho","orcid":null,"position":5,"is_corresponding":false},{"id":114423,"name":"Yong Cao","orcid":null,"position":6,"is_corresponding":false},{"id":1561530,"name":"Yunjiao Chen","orcid":null,"position":7,"is_corresponding":false},{"id":1561523,"name":"Chunxiu Lin","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Rosmarinic acid regulates lipid accumulation through lipid metabolism and anti-inflammatory","abstract":"Obesity caused by poor eating habits has become a global public health issue and harms human health. Rosmarinic acid (RA) is a natural active substance with many biological functions like antioxidant. However, the function of RA’s lipid-lowering effect and mechanism are not entirely clear. This study aimed to explore the effect of RA on obesity and its action mechanism in <em>Caenorhabditis elegans</em>. RA not only alleviated intestinal inflammation and change the composition of unsaturated fatty acid, but also decreased fat storage and adjusted the size and quantity of fat droplets without threatening development and reproduction or affecting energy intake. In addition, RA improved the integrity of intestinal barrier function in <em>C. elegans</em>. RNA sequencing and qRT-PCR comprehensively revealed that the lipid-lowering mechanism mediated by RA might involve lipid metabolism and anti-inflammatory pathways. Among them, RA regulates lipid metabolism by reducing fat synthesis through SBP-1and increasing fatty acid β-oxidation via NHR-49. Furthermore, the anti-inflammatory pathway was associated with RA’s enhancement of the ratio of unsaturated fatty acid and alleviation of inflammatory reactions caused by PAO1. Therefore, RA regulated lipid metabolism and relieved inflammation, which had the potential for dietary supplements or functional foods.","is_dataset_classified":null,"base_score":1.3862943611198906,"endowment":1.3862943611198906,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W4399354255","authors":[],"funders":[],"total_grants":0,"fwci":0.6959,"citation_percentile":0.65501431,"influential_citations":0,"citation_trend":[{"year":2025,"count":1},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by-nc-nd","oa_locations":[{"url":"https://sciopen.com/article_pdf/1793524805553201154.pdf","host_type":"journal"},{"url":"https://sciopen.com/article_pdf/1793524805553201154.pdf","host_type":"publisher"},{"url":"https://doi.org/10.26599/fshw.2024.9250121","host_type":"journal"},{"url":"https://doaj.org/article/1a6bd381f9f14eab85934fb37df370f6","host_type":"repository"}],"fields_of_study":["Fatty Acid Research and Health","Adipose Tissue and Metabolism","Metabolomics and Mass Spectrometry Studies"],"mesh_terms":[],"keywords":["Rosmarinic acid","Lipid metabolism","Lipid accumulation","Chemistry","Metabolism","Lipid droplet","Biochemistry","Antioxidant"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T07:26:22.078870Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}