{"doi":"10.26508/lsa.202403021","title":"lncRNA <i>CARINH</i> regulates expression and function of innate immune transcription factor IRF1 in macrophages","abstract":"The discovery of long non-coding RNAs (lncRNAs) has provided a new perspective on the centrality of RNA in gene regulation and genome organization. Here, we screened for lncRNAs with putative functions in the host response to single-stranded RNA respiratory viruses. We identify CARINH as a conserved cis-acting lncRNA up-regulated in three respiratory diseases to control the expression of its antisense gene IRF1 , a key transcriptional regulator of the antiviral response. CARINH and IRF1 are coordinately increased in the circulation of patients infected with human metapneumovirus, influenza A virus, or SARS-CoV-2, and in macrophages in response to viral infection or TLR3 agonist treatment. Targeted depletion of CARINH or its mouse ortholog Carinh in macrophages reduces the expression of IRF1/Irf1 and their associated target gene networks, increasing susceptibility to viral infection. Accordingly, CRISPR-mediated deletion of Carinh in mice reduces antiviral immunity, increasing viral burden upon sublethal challenge with influenza A virus. Together, these findings identify a conserved role of lncRNA CARINH in coordinating interferon-stimulated genes and antiviral immune responses.","journal":"Life Science Alliance","year":2025,"id":517662,"datarank":0.31191623125197543,"base_score":2.0794415416798357,"endowment":2.0794415416798357,"self_citation_contribution":0.31191623125197543,"citation_network_contribution":0.0,"self_endowment_contribution":0.31191623125197543,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":7,"citer_count":5,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9507,"is_data_producer":true,"deposit_databanks":{"GEO":["GSE275288","GSE247501","GSE261123"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":865668,"name":"Morgane Gourvest","orcid":"0000-0003-4095-6691","position":1,"is_corresponding":false},{"id":988240,"name":"Grace O. Ciabattoni","orcid":"0000-0002-2453-9380","position":2,"is_corresponding":false},{"id":425020,"name":"Tracy Zhang","orcid":"0000-0002-4325-8533","position":3,"is_corresponding":false},{"id":236644,"name":"Alexandra Newman","orcid":"0000-0001-8938-2428","position":4,"is_corresponding":false},{"id":567590,"name":"Tarik Zahr","orcid":"0000-0002-2754-6092","position":5,"is_corresponding":false},{"id":504359,"name":"Sofie Delbare","orcid":"0000-0001-7964-3962","position":6,"is_corresponding":false},{"id":258250,"name":"Florencia Schlamp","orcid":"0000-0003-3319-6778","position":7,"is_corresponding":false},{"id":550102,"name":"Meike Dittmann","orcid":"0000-0002-1741-7916","position":8,"is_corresponding":false},{"id":236657,"name":"Kathryn J. Moore","orcid":"0000-0003-2505-2547","position":9,"is_corresponding":false},{"id":236646,"name":"Coen van Solingen","orcid":"0000-0002-5817-2003","position":10,"is_corresponding":false},{"id":668459,"name":"Yannick Cyr","orcid":null,"position":0,"is_corresponding":true}],"reference_count":70,"raw_metadata":null,"created_at":"2026-07-19T02:48:59.410472Z","pmid":"39773901","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}