{"doi":"10.26508/lsa.202101180","title":"Autoimmune anti-DNA and anti-phosphatidylserine antibodies predict development of severe COVID-19","abstract":"High levels of autoimmune antibodies are observed in COVID-19 patients but their specific contribution to disease severity and clinical manifestations remains poorly understood. We performed a retrospective study of 115 COVID-19 hospitalized patients with different degrees of severity to analyze the generation of autoimmune antibodies to common antigens: a lysate of erythrocytes, the lipid phosphatidylserine (PS) and DNA. High levels of IgG autoantibodies against erythrocyte lysates were observed in a large percentage (up to 36%) of patients. Anti-DNA and anti-PS antibodies determined upon hospital admission correlated strongly with later development of severe disease, showing a positive predictive value of 85.7% and 92.8%, respectively. Patients with positive values for at least one of the two autoantibodies accounted for 24% of total severe cases. Statistical analysis identified strong correlations between anti-DNA antibodies and markers of cell injury, coagulation, neutrophil levels and erythrocyte size. Anti-DNA and anti-PS autoantibodies may play an important role in the pathogenesis of COVID-19 and could be developed as predictive biomarkers for disease severity and specific clinical manifestations.","journal":"Life Science Alliance","year":2021,"id":171105,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":27,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9656,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":705687,"name":"Marisol Zuniga","orcid":null,"position":1,"is_corresponding":false},{"id":704939,"name":"Kelly Crotty","orcid":"0000-0001-8462-5275","position":2,"is_corresponding":false},{"id":385141,"name":"Kun Qian","orcid":"0000-0002-3196-9258","position":3,"is_corresponding":false},{"id":507415,"name":"Nubia Catalina Tovar","orcid":null,"position":4,"is_corresponding":false},{"id":246055,"name":"Lawrence Hsu Lin","orcid":"0000-0001-9603-9783","position":5,"is_corresponding":false},{"id":246045,"name":"Kimon V. Argyropoulos","orcid":"0000-0003-1510-5887","position":6,"is_corresponding":false},{"id":285330,"name":"Robert M. Clancy","orcid":"0000-0003-1151-0084","position":7,"is_corresponding":false},{"id":255415,"name":"Peter Izmirly","orcid":"0000-0001-5445-2182","position":8,"is_corresponding":false},{"id":255416,"name":"Jill P. Buyon","orcid":"0000-0002-3852-7129","position":9,"is_corresponding":false},{"id":530031,"name":"David C. Lee","orcid":"0000-0002-7202-1893","position":10,"is_corresponding":false},{"id":481594,"name":"María Fernanda Yasnot","orcid":"0000-0001-8081-4212","position":11,"is_corresponding":false},{"id":315159,"name":"Huilin Li","orcid":"0000-0002-8288-7068","position":12,"is_corresponding":false},{"id":236057,"name":"Paolo Cotzia","orcid":"0000-0002-0710-7631","position":13,"is_corresponding":false},{"id":481595,"name":"Ana Rodrı́guez","orcid":"0000-0002-0060-3405","position":14,"is_corresponding":false},{"id":704938,"name":"Cláudia Gomes","orcid":"0000-0003-3746-1671","position":0,"is_corresponding":true}],"reference_count":38,"raw_metadata":null,"created_at":"2026-07-18T23:46:28.747384Z","pmid":"34504035","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}