{"doi":"10.26508/lsa.202101056","title":"Dendritic cells maintain anti-tumor immunity by positioning CD8 skin-resident memory T cells","abstract":"Tissue-resident memory (T RM ) T cells are emerging as critical components of the immune response to cancer; yet, requirements for their ongoing function and maintenance remain unclear. APCs promote T RM cell differentiation and re-activation but have not been implicated in sustaining T RM cell responses. Here, we identified a novel role for dendritic cells in supporting T RM to melanoma. We showed that CD8 T RM cells remain in close proximity to dendritic cells in the skin. Depletion of CD11c + cells results in rapid disaggregation and eventual loss of melanoma-specific T RM cells. In addition, we determined that T RM migration and/or persistence requires chemotaxis and adhesion mediated by the CXCR6/CXCL16 axis. The interaction between CXCR6-expressing T RM cells and CXCL16-expressing APCs was found to be critical for sustaining T RM cell–mediated tumor protection. These findings substantially expand our knowledge of APC functions in T RM T-cell homeostasis and longevity.","journal":"Life Science Alliance","year":2021,"id":163632,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9483,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":626339,"name":"Aleksey Molodtsov","orcid":"0000-0002-4629-808X","position":1,"is_corresponding":false},{"id":242857,"name":"Christina V. Angeles","orcid":"0000-0002-6500-9589","position":2,"is_corresponding":false},{"id":392930,"name":"Bruce R. Branchini","orcid":"0000-0001-5635-5087","position":3,"is_corresponding":false},{"id":242856,"name":"Mary Jo Turk","orcid":"0000-0002-9612-8329","position":4,"is_corresponding":false},{"id":292415,"name":"Yina H. Huang","orcid":"0000-0002-0125-9351","position":5,"is_corresponding":false},{"id":626340,"name":"Jennifer L. Vella","orcid":"0000-0002-6190-8114","position":0,"is_corresponding":true}],"reference_count":69,"raw_metadata":null,"created_at":"2026-07-18T23:45:22.477398Z","pmid":"34362825","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}