{"doi":"10.26508/lsa.202000886","title":"SARS-CoV-2 infection induces protective immunity and limits transmission in Syrian hamsters","abstract":"A critical question in understanding the immunity to SARS-COV-2 is whether recovered patients are protected against re-challenge and transmission upon second exposure. We developed a Syrian hamster model in which intranasal inoculation of just 100 TCID 50 virus caused viral pneumonia. Aged hamsters developed more severe disease and even succumbed to SARS-CoV-2 infection, representing the first lethal model using genetically unmodified laboratory animals. After initial viral clearance, the hamsters were re-challenged with 10 5 TCID 50 SARS-CoV-2 and displayed more than 4 log reduction in median viral loads in both nasal washes and lungs in comparison to primary infections. Most importantly, re-challenged hamsters were unable to transmit virus to naïve hamsters, and this was accompanied by the presence of neutralizing antibodies. Altogether, these results show that SARS-CoV-2 infection induces protective immunity that not only prevents re-exposure but also limits transmission in hamsters. These findings may help guide public health policies and vaccine development and aid evaluation of effective vaccines against SARS-CoV-2.","journal":"Life Science Alliance","year":2021,"id":156882,"datarank":1.9412041143637013,"base_score":3.970291913552122,"endowment":3.970291913552122,"self_citation_contribution":0.5955437870328184,"citation_network_contribution":1.345660327330883,"self_endowment_contribution":0.5955437870328184,"citer_contribution":1.345660327330883,"corpus_percentile":null,"corpus_rank":null,"citation_count":52,"citer_count":37,"citers_with_citation_signal":35,"citers_with_endowment":35,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9561,"is_data_producer":true,"deposit_databanks":{"GENBANK":["NC_045512"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2021-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":550814,"name":"Christopher Z. Lien","orcid":"0000-0002-2572-887X","position":1,"is_corresponding":false},{"id":550815,"name":"Shufeng Liu","orcid":"0000-0001-9969-6041","position":2,"is_corresponding":false},{"id":320714,"name":"Charles B. Stauft","orcid":"0000-0001-5633-2950","position":3,"is_corresponding":false},{"id":662421,"name":"Ivette A. Nuñez","orcid":"0000-0003-3213-3628","position":4,"is_corresponding":false},{"id":662834,"name":"Mario Hernández","orcid":null,"position":5,"is_corresponding":false},{"id":662835,"name":"Eric Nimako","orcid":null,"position":6,"is_corresponding":false},{"id":662836,"name":"Mario A Ortega","orcid":null,"position":7,"is_corresponding":false},{"id":389943,"name":"Matthew F. Starost","orcid":"0000-0002-6234-4875","position":8,"is_corresponding":false},{"id":662422,"name":"John U. Dennis","orcid":"0000-0003-2435-2521","position":9,"is_corresponding":false},{"id":313412,"name":"Tony T. Wang","orcid":"0000-0001-8983-1721","position":10,"is_corresponding":false},{"id":552606,"name":"Prabhuanand Selvaraj","orcid":"0000-0001-7266-3928","position":0,"is_corresponding":true}],"reference_count":22,"raw_metadata":null,"created_at":"2026-07-18T23:44:13.017332Z","pmid":"33574037","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}