{"doi":"10.26508/lsa.202000766","title":"Egr2 and 3 control inflammation, but maintain homeostasis, of PD-1<sup>high</sup>memory phenotype CD4 T cells","abstract":"The transcription factors Egr2 and 3 are essential for controlling inflammatory autoimmune responses of memory phenotype (MP) CD4 T cells. However, the mechanism is still unclear. We have now found that the Egr2 + subset (PD-1 high MP) of MP CD4 T cells expresses high levels of checkpoint molecules (PD-1 and Lag3) and also markers of effector T cells (CXCR3 and ICAM-1). Egr2/3 are not required for PD-1 high MP CD4 cell development but mediate a unique transcriptional programme that effectively controls their inflammatory responses, while promoting homeostatic proliferation and adaptive responses. Egr2 negative PD-1 high MP CD4 T cells are impaired in homeostatic proliferation and adaptive responses against viral infection but display inflammatory responses to innate stimulation such as IL-12. PD-1 high MP CD4 T cells have recently been implicated in rheumatoid arthritis pathogenesis, and we have now found that Egr2 expression is reduced in PD-1 high MP CD4 T cells from patients with active rheumatoid arthritis compared with healthy controls. These findings demonstrate that Egr2/3 control the inflammatory responses of PD-1 high MP CD4 T cells and maintain their adaptive immune fitness.","journal":"Life Science Alliance","year":2020,"id":70530,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":19,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9457,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":373412,"name":"Wei Zheng","orcid":"0000-0002-1741-7537","position":1,"is_corresponding":false},{"id":375074,"name":"Tizong Miao","orcid":null,"position":2,"is_corresponding":false},{"id":373413,"name":"Haiyu Wang","orcid":"0000-0002-1764-4385","position":3,"is_corresponding":false},{"id":375075,"name":"Tieshang Wang","orcid":null,"position":4,"is_corresponding":false},{"id":375076,"name":"Ruth Kiome","orcid":null,"position":5,"is_corresponding":false},{"id":373414,"name":"Xiujuan Hou","orcid":"0000-0002-1236-6849","position":6,"is_corresponding":false},{"id":373415,"name":"Suling Li","orcid":"0000-0001-8756-9336","position":7,"is_corresponding":false},{"id":366357,"name":"Ping Wang","orcid":"0000-0001-8992-1233","position":8,"is_corresponding":false},{"id":373411,"name":"Alistair L. J. Symonds","orcid":"0000-0002-9461-0816","position":0,"is_corresponding":true}],"reference_count":80,"raw_metadata":null,"created_at":"2026-07-18T21:43:32.585486Z","pmid":"32709717","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}