{"doi":"10.26508/lsa.201900581","title":"Repression of SMAD3 by STAT3 and c-Ski induces conventional dendritic cell differentiation","abstract":"A pleiotropic immunoregulatory cytokine, TGF-β, signals via the receptor-regulated SMADs: SMAD2 and SMAD3, which are constitutively expressed in normal cells. Here, we show that selective repression of SMAD3 induces cDC differentiation from the CD115 + common DC progenitor (CDP). SMAD3 was expressed in haematopoietic cells including the macrophage DC progenitor. However, SMAD3 was specifically down-regulated in CD115 + CDPs, SiglecH - pre-DCs, and cDCs, whereas SMAD2 remained constitutive. SMAD3-deficient mice showed a significant increase in cDCs, SiglecH − pre-DCs, and CD115 + CDPs compared with the littermate control. SMAD3 repressed the mRNA expression of FLT3 and the cDC-related genes: IRF4 and ID2. We found that one of the SMAD transcriptional corepressors, c-SKI, cooperated with phosphorylated STAT3 at Y705 and S727 to repress the transcription of SMAD3 to induce cDC differentiation. These data indicate that STAT3 and c-Ski induce cDC differentiation by repressing SMAD3: the repressor of the cDC-related genes during the developmental stage between the macrophage DC progenitor and CD115 + CDP.","journal":"Life Science Alliance","year":2024,"id":480584,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9552,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1320117,"name":"Eunjin Bae","orcid":"0000-0001-6526-6369","position":1,"is_corresponding":false},{"id":1320118,"name":"Yasuo Nagafuchi","orcid":"0000-0002-1316-8035","position":2,"is_corresponding":false},{"id":447883,"name":"Katsuko Sudo","orcid":"0000-0002-5286-7648","position":3,"is_corresponding":false},{"id":1320119,"name":"Jin Soo Han","orcid":"0000-0003-2136-1932","position":4,"is_corresponding":false},{"id":1320120,"name":"Seok Hee Park","orcid":"0000-0002-6210-4927","position":5,"is_corresponding":false},{"id":1030833,"name":"Susumu Nakae","orcid":"0000-0002-8988-0256","position":6,"is_corresponding":false},{"id":1316706,"name":"Tadashi Yamashita","orcid":"0000-0001-8022-0158","position":7,"is_corresponding":false},{"id":1320121,"name":"Ji Hyeon Ju","orcid":"0000-0002-1381-5466","position":8,"is_corresponding":false},{"id":749452,"name":"Isao Matsumoto","orcid":"0000-0002-7995-9294","position":9,"is_corresponding":false},{"id":209791,"name":"Takayuki Sumida","orcid":null,"position":10,"is_corresponding":false},{"id":1320122,"name":"Keiji Miyazawa","orcid":"0000-0002-7835-7718","position":11,"is_corresponding":false},{"id":1320123,"name":"Mitsuyasu Kato","orcid":"0000-0001-9905-2473","position":12,"is_corresponding":false},{"id":447885,"name":"Masahiko Kuroda","orcid":"0000-0001-7052-4289","position":13,"is_corresponding":false},{"id":40453,"name":"In‐Kyu Lee","orcid":"0000-0002-2261-7269","position":14,"is_corresponding":false},{"id":49160,"name":"Keishi Fujio","orcid":"0000-0001-7276-5254","position":15,"is_corresponding":false},{"id":1181588,"name":"Mizuko Mamura","orcid":"0000-0003-4531-0144","position":16,"is_corresponding":false},{"id":1320116,"name":"Jeong‐Hwan Yoon","orcid":"0000-0001-6445-1036","position":0,"is_corresponding":true}],"reference_count":85,"raw_metadata":null,"created_at":"2026-07-19T02:07:02.142014Z","pmid":"38960622","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}