{"doi":"10.26434/chemrxiv.10314647.v2","title":"[18F]SuFEx Click Chemistry Enabled Ultrafast Late-stage Radiosynthesis","abstract":"The lack of simple, efficient [ 18 F]fluorination processes and new target-specific organofluorine probes remains the major challenge of fluorine-18-based positron emission tomography (PET). We report here a fast isotopic exchange method for the radiosynthesis of aryl [ 18 F]fluorosulfate based PET agents enabled by the emerging sulfur fluoride exchange (SuFEx) click chemistry. The method has been applied to the fully-automated 18 F-radiolabeling of twenty-five structurally diverse aryl fluorosulfates with excellent radiochemical yield (83–100%) and high molar activity (up to 281 GBq µmol –1 ) at room temperature in 30 seconds. The purification of radiotracers requires no time-consuming high-performance liquid chromatography (HPLC), but rather a simple cartridge filtration. The utility of aryl [ 18 F]fluorosulfate is demonstrated by the in vivo tumor imaging by targeting poly(ADP-ribose) polymerase 1 (PARP1).","journal":"ChemRxiv","year":2020,"id":125844,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9576,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":572766,"name":"Hongtao Xu","orcid":"0000-0001-5174-9079","position":1,"is_corresponding":false},{"id":572767,"name":"Hua Wang","orcid":"0000-0002-2976-9521","position":2,"is_corresponding":false},{"id":573293,"name":"Wen-Ge Han Du","orcid":null,"position":3,"is_corresponding":false},{"id":383637,"name":"Nan Wang","orcid":"0000-0002-7616-8083","position":4,"is_corresponding":false},{"id":572768,"name":"Huan Xiong","orcid":"0000-0002-7191-3259","position":5,"is_corresponding":false},{"id":573294,"name":"Yuang Gu","orcid":null,"position":6,"is_corresponding":false},{"id":404400,"name":"Louis Noodleman","orcid":"0000-0001-8176-4448","position":7,"is_corresponding":false},{"id":572769,"name":"Guang Yang","orcid":"0000-0003-4240-8197","position":8,"is_corresponding":false},{"id":74387,"name":"K. Barry Sharpless","orcid":"0000-0001-6051-1599","position":9,"is_corresponding":false},{"id":262641,"name":"Peng Wu","orcid":"0000-0002-5204-0229","position":10,"is_corresponding":false},{"id":563493,"name":"Qinheng Zheng","orcid":"0000-0002-8440-8673","position":0,"is_corresponding":true}],"reference_count":40,"raw_metadata":null,"created_at":"2026-07-18T23:15:19.482428Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}