{"doi":"10.26355/eurrev_202003_20547","title":"Effects of aging and life-long moderate calorie restriction on IL-15 signaling in the rat white adipose tissue.","abstract":"OBJECTIVE: Phosphorylation of insulin receptor substrate (IRS) 1 by tumor necrosis factor alpha (TNF-α) has been implicated as a factor contributing to insulin resistance. Administration of IL-15 reduces adipose tissue deposition in young rats and stimulates secretion of adiponectin, an insulin sensitizing hormone that inhibits the production and activity of TNF-α. We aimed at investigating the effects of age life-long moderate calorie restriction (CR) on IL-15 and TNF-α signaling in rat white adipose tissue (WAT). MATERIALS AND METHODS: Thirty-six 8-month-old, 18-month-old, and 29-month-old male Fischer344´Brown Norway F1 rats (6 per group) were either fed ad libitum (AL) or calorie restricted by 40%. The serum levels of IL-15 and IL-15 receptor α-chain (IL-15Rα) were increased by CR controls regardless of age. An opposite pattern was detected in WAT. In addition, CR reduced gene expression of TNF-α and cytosolic IRS1 serine phosphorylation in WAT, independently from age. RESULTS: IL-15 signaling in WAT is increased over the course of aging in AL rats compared with CR rodents. Protein levels of IL-15Rα are greater in WAT of AL than in CR rats independently from age. This adaptation was paralleled by increased IRS1 phosphorylation through TNF-α-mediated insulin resistance. Adiponectin decreased at old age in AL rats, while no changes were evident in CR rats across age groups. CONCLUSIONS: IL-15 signaling could therefore represent a potential target for interventions to counteract metabolic alterations and the deterioration of body composition during aging.","journal":"PubMed","year":2020,"id":108931,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":3,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9531,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":521621,"name":"C.S. Carter","orcid":null,"position":1,"is_corresponding":false},{"id":329404,"name":"Christiaan Leeuwenburgh","orcid":"0000-0003-0826-4257","position":2,"is_corresponding":false},{"id":520867,"name":"Andrea Flex","orcid":"0000-0003-2664-4165","position":3,"is_corresponding":false},{"id":520868,"name":"Federico Biscetti","orcid":"0000-0001-7449-657X","position":4,"is_corresponding":false},{"id":521622,"name":"Drake Morgan","orcid":null,"position":5,"is_corresponding":false},{"id":520869,"name":"Alice Laudisio","orcid":"0000-0002-6167-053X","position":6,"is_corresponding":false},{"id":520870,"name":"Daniele Coraci","orcid":"0000-0002-7019-9006","position":7,"is_corresponding":false},{"id":520871,"name":"Giulio Maccauro","orcid":"0000-0002-7359-268X","position":8,"is_corresponding":false},{"id":520872,"name":"Giuseppe Zuccalà","orcid":"0000-0002-2567-2220","position":9,"is_corresponding":false},{"id":520873,"name":"Pietro Caliandro","orcid":"0000-0002-1190-4879","position":10,"is_corresponding":false},{"id":521623,"name":"R Bernabei","orcid":null,"position":11,"is_corresponding":false},{"id":520874,"name":"Emanuele Marzetti","orcid":"0000-0001-9567-6983","position":12,"is_corresponding":false},{"id":520866,"name":"Silvia Giovannini","orcid":"0000-0001-9125-752X","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:12:46.854423Z","pmid":"32196625","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}