{"doi":"10.26180/5e68787f20ecf","title":"therapeutic targeting of OLIG2 in high grade glioma","abstract":"CT-179 is a world first, small molecule drug designated for specific targeting of a transcription factor named OLIG2. This thesis investigates the working mechanism and efficacy of CT-179 for the treatment of the most malignant brain tumour, glioblastoma. Mechanistically, CT-179 inhibits OLIG2 biological function through destabilizing its interaction with target DNA, and induces significant tumour cell death in cell lines. In the zebrafish and mouse models of glioblastoma, CT-179 can penetrate the blood-brain barrier, and significantly reduce tumour burden. Importantly, it shows enhanced anti-tumour activity when used in combination with standard of care radiotherapy and temozolomide, suggesting that CT-179 could be added to the current standard of care treatment to improve patient outcome. These studies demonstrates that the pharmacological inhibition of OLIG2 is a promising treatment strategy for glioblastoma that warrants rapid translation into the clinic.","journal":"Nineteenth-Century Literature","year":2020,"id":129405,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9564,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":580625,"name":"Shengnan Chen","orcid":"0000-0003-0899-1868","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-18T23:15:45.920615Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}