{"doi":"10.2500/ar.2016.7.0183","title":"Prevalence of Allergic Sensitization to Conifer Pollen in a High Cypress Exposure Area","abstract":"<jats:sec>\n                    <jats:title>Background</jats:title>\n                    <jats:p>Sensitization to Finales (Cupressaceae and Pinaceae) has increased dramatically in recent years. The prevalence of sensitization in different geographic areas is related to exposure to specific pollens.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives</jats:title>\n                    <jats:p>To investigate the prevalence of allergy to different conifer pollens, describe the characteristics of patients with such allergy, and identify the involved allergens.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods</jats:title>\n                    <jats:p>Patients were recruited at five hospitals near Madrid. Extracts from conifer pollen were prepared and used in skin-prick testing. Wheal sizes were recorded, and serum samples obtained from patients with positive reactions to Cupressus arizonica and/or Pinus pinea. The specific immunoglobulin E value to C. arizonica and Cup a 1 was determined. Individual immunoblots for each patient and with a pool of sera were performed. Allergenic proteins were sequenced by using liquid chromatography-tandem mass spectrometry.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Results</jats:title>\n                    <jats:p>Of 499 individuals included in the study, 17 (14%) had positive skin-prick test results to some conifer pollen extracts. Sixty-four patients had positive results to C. arizonica (prevalence 12.8%) and 11 had positive results to P. pinea (2.2%). All the patients had respiratory symptoms (61.4% during the C. arizonica pollination period), and 62.9% had asthma. Approximately 86% of the patients had positive specific immunoglobulin E results to C. arizonica and 923% had positive results to Cup a 1. Fourteen different bands were recognized by immunoblot; the most frequent bands were those detected at 43, 18, 16, and 14 kDa. All sequenced proteins corresponded to Cup a 1.</jats:p>\n                  </jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion</jats:title>\n                    <jats:p>Allergy to conifer pollen could be considered a relevant cause of respiratory allergy in central Spain. Asthma was more frequent than in other studies. We only identified Cup a 1 as involved in sensitization.</jats:p>\n                  </jats:sec>","journal":"Allergy &amp; Rhinology","year":2016,"id":31400,"datarank":0.9455996670147784,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"self_citation_contribution":0.44166584687496613,"citation_network_contribution":0.5039338201398122,"self_endowment_contribution":0.44166584687496613,"citer_contribution":0.5039338201398122,"corpus_percentile":null,"corpus_rank":null,"citation_count":18,"citer_count":16,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":168402,"name":"María Ángeles López-Matas","orcid":null,"position":1,"is_corresponding":false},{"id":168403,"name":"María Dolores Alonso","orcid":null,"position":2,"is_corresponding":false},{"id":168404,"name":"Angélica Feliu","orcid":null,"position":3,"is_corresponding":false},{"id":168405,"name":"Javier Ruiz-Hornillos","orcid":null,"position":4,"is_corresponding":false},{"id":168406,"name":"Emma González","orcid":null,"position":5,"is_corresponding":false},{"id":168407,"name":"Raquel Moya","orcid":null,"position":6,"is_corresponding":false},{"id":168408,"name":"Jerónimo Carnés","orcid":null,"position":7,"is_corresponding":false},{"id":168401,"name":"Javier Domínguez-Ortega","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.9444389791664403,"endowment":2.9444389791664403,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"28683246","pmcid":"PMC5244279","openalex_id":"https://openalex.org/W2578301651","authors":[],"funders":[],"total_grants":0,"fwci":1.3358,"citation_percentile":0.80263491,"influential_citations":2,"citation_trend":[{"year":2018,"count":3},{"year":2019,"count":3},{"year":2020,"count":2},{"year":2021,"count":1},{"year":2022,"count":2},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":3},{"year":2026,"count":2}],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.2500/ar.2016.7.0183","host_type":"journal"},{"url":"https://journals.sagepub.com/doi/pdf/10.2500/ar.2016.7.0183","host_type":"GOLD"},{"url":"https://journals.sagepub.com/doi/pdf/10.2500/ar.2016.7.0183","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.2500/ar.2016.7.0183","host_type":"publisher"},{"url":"https://doi.org/10.2500/ar.2016.7.0183","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/28683246","host_type":"repository"},{"url":"https://repositoriosaludmadrid.es/handle/20.500.12530/28051","host_type":"repository"},{"url":"https://doaj.org/article/7d27c4eaf93c4fbab648e9fb4f0a3edb","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/5244279","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC5244279","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC5244279?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Allergic Rhinitis and Sensitization","Contact Dermatitis and Allergies","Asthma and respiratory diseases","Medicine","Biology","Environmental Science"],"mesh_terms":[],"keywords":["Cypress","Pollen","Sensitization","Botany","Cupressus","Chemistry","Biology","Immunology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Life in Land"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T07:05:02.306359Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}