{"doi":"10.24966/avs-7397/vol10iss1","title":"Untitled","abstract":"Although the platelet thrombus in the coronary, cerebral and peripheral artery systems is the number one killer, there is no clinically relevant platelet biomarker for this devastating pathology, since the discovery of blood circulation in a closed by William Harvey (1628, De Motu Cordis) and the triple synergistic effects of I. Hypercoagulability of blood viscosity, II.Blood flow stasis-flow disturbance and III.Arterial wall injury from the loss of endothelial cells as in Rudolf Virchow's Triad resulting in the deep vein thrombosis (DVT) and arterial platelet thrombus formation in 1856.Out of ~60,000 miles of arteries, veins and capillary network in the human circulatory system, the coronary artery system of narrow arteries (~2-5 mm ID) with multiple branching, twisting and higher shear force is the most vulnerable ~25 cm component.Clinicians still use the International Normalized Ratio (INR) involving the extrinsic and common coagulation pathway for the effectiveness of drug therapy in the affected patients.In the absence of any critical biomarker of thrombogenicity during almost 120 years for a thrombotic heart attack and stroke, I developed the first parameter of regional platelet density (RPD) in the adherent platelet thrombus (APT) in 1978 in the canine model coronary of left anterior descending (LAD) artery bypass graft surgery.In 1976,","journal":"Angiology & Vascular Surgery","year":2025,"id":587812,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9593,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:59:39.958043Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}