{"doi":"10.2478/jomb-2018-0052","title":"The importance of RET-He in the diagnosis of iron deficiency and iron deficiency anemia and the evaluation of response to oral iron therapy","abstract":"<jats:title>Summary</jats:title><jats:sec id=\"j_jomb-2018-0052_s_006\"><jats:title>Background</jats:title><jats:p>The purpose of this study is to investigate whether or not reticulocyte hemoglobin equivalent (RET-He) is a superior indicator of blood count and other iron parameters in terms of diagnosing iron deficiency (ID) and iron deficiency anemia (IDA), and thus evaluating a patient’s response to oral iron treatment.</jats:p></jats:sec><jats:sec id=\"j_jomb-2018-0052_s_007\"><jats:title>Methods</jats:title><jats:p>The research population consisted of 217 participants in total: 54 control, 53 ID, 58 non-ID anemia, and 52 IDA patients. A hemoglobin (Hb) value of &lt; 130.0 g/L was defined as indicating anemia for men, while an Hb value of &lt; 120.0 g/L was defined as indicating anemia for women. All patients were administered 270 mg oral elemental iron sulphate daily.</jats:p></jats:sec><jats:sec id=\"j_jomb-2018-0052_s_008\"><jats:title>Results</jats:title><jats:p>The RET-He was significantly lower in the IDA group, compared to other groups (IDA: 21.0 ± 4.1, ID: 26.0 ± 4.9, non-ID anemia: 32.1 ± 6.8, control: 36.6 ± 7.0; &lt; 0.001). The ID group had a lower RET-He compared to the non-ID anemia group and the control group. On the 5th day of treatment, the ID and IDA group showed no significant differences in terms of Hb while the RET-He level demonstrated a significant increase. The increase in the RET-He level observed in the IDA group on the 5th day was significantly higher compared to the increase observed in the ID group. A RET-He value of 25.4 pg and below predicted ID diagnosis with 90.4% sensitivity and 49.1% specificity in IDA patients, compared to the ID group.</jats:p></jats:sec><jats:sec id=\"j_jomb-2018-0052_s_009\"><jats:title>Conclusions</jats:title><jats:p>The results of our study, therefore, suggest that RET-He may be a clinically useful marker in the diagnosis of ID and IDA.</jats:p></jats:sec>","journal":"Journal of Medical Biochemistry","year":2019,"id":678366,"datarank":0.5606504427425053,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"self_citation_contribution":0.5606504427425053,"citation_network_contribution":0.0,"self_endowment_contribution":0.5606504427425053,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":41,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1772428,"name":"Mesude Falay","orcid":null,"position":1,"is_corresponding":false},{"id":1772429,"name":"Simten Dağdas","orcid":null,"position":2,"is_corresponding":false},{"id":1772432,"name":"Funda Ceran","orcid":null,"position":3,"is_corresponding":false},{"id":1772435,"name":"Selin Merih Urlu","orcid":null,"position":4,"is_corresponding":false},{"id":1772437,"name":"Gülsüm Özet","orcid":null,"position":5,"is_corresponding":false},{"id":1772425,"name":"Mehmet Ali Uçar","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The importance of RET-He in the diagnosis of iron deficiency and iron deficiency anemia and the evaluation of response to oral iron therapy","abstract":"<jats:title>Summary</jats:title><jats:sec id=\"j_jomb-2018-0052_s_006\"><jats:title>Background</jats:title><jats:p>The purpose of this study is to investigate whether or not reticulocyte hemoglobin equivalent (RET-He) is a superior indicator of blood count and other iron parameters in terms of diagnosing iron deficiency (ID) and iron deficiency anemia (IDA), and thus evaluating a patient’s response to oral iron treatment.</jats:p></jats:sec><jats:sec id=\"j_jomb-2018-0052_s_007\"><jats:title>Methods</jats:title><jats:p>The research population consisted of 217 participants in total: 54 control, 53 ID, 58 non-ID anemia, and 52 IDA patients. A hemoglobin (Hb) value of &lt; 130.0 g/L was defined as indicating anemia for men, while an Hb value of &lt; 120.0 g/L was defined as indicating anemia for women. All patients were administered 270 mg oral elemental iron sulphate daily.</jats:p></jats:sec><jats:sec id=\"j_jomb-2018-0052_s_008\"><jats:title>Results</jats:title><jats:p>The RET-He was significantly lower in the IDA group, compared to other groups (IDA: 21.0 ± 4.1, ID: 26.0 ± 4.9, non-ID anemia: 32.1 ± 6.8, control: 36.6 ± 7.0; &lt; 0.001). The ID group had a lower RET-He compared to the non-ID anemia group and the control group. On the 5th day of treatment, the ID and IDA group showed no significant differences in terms of Hb while the RET-He level demonstrated a significant increase. The increase in the RET-He level observed in the IDA group on the 5th day was significantly higher compared to the increase observed in the ID group. A RET-He value of 25.4 pg and below predicted ID diagnosis with 90.4% sensitivity and 49.1% specificity in IDA patients, compared to the ID group.</jats:p></jats:sec><jats:sec id=\"j_jomb-2018-0052_s_009\"><jats:title>Conclusions</jats:title><jats:p>The results of our study, therefore, suggest that RET-He may be a clinically useful marker in the diagnosis of ID and IDA.</jats:p></jats:sec>","is_dataset_classified":null,"base_score":3.7376696182833684,"endowment":3.7376696182833684,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"31496915","pmcid":"PMC6708300","openalex_id":"https://openalex.org/W2914302157","authors":[],"funders":[],"total_grants":0,"fwci":2.3638,"citation_percentile":0.89166836,"influential_citations":0,"citation_trend":[{"year":2020,"count":5},{"year":2021,"count":3},{"year":2022,"count":9},{"year":2023,"count":8},{"year":2024,"count":9},{"year":2025,"count":4},{"year":2026,"count":3}],"oa_status":"gold","license":"cc-by","oa_locations":[{"url":"https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581904496A.pdf","host_type":"journal"},{"url":"https://scindeks-clanci.ceon.rs/data/pdf/1452-8258/2019/1452-82581904496A.pdf","host_type":"publisher"},{"url":"http://content.sciendo.com/view/journals/jomb/38/4/article-p496.xml","host_type":"publisher"},{"url":"https://doi.org/10.2478/jomb-2018-0052","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/31496915","host_type":"repository"},{"url":"https://avesis.aybu.edu.tr/publication/details/9c7c55e2-2017-44c8-bae9-169b2907d19e/oai","host_type":"repository"},{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/6708300","host_type":"repository"},{"url":"https://doaj.org/article/27250da2b91b4ae18645d6176de6aaf1","host_type":"repository"},{"url":"https://avesis.aybu.edu.tr/publication/details/9c7c55e2-2017-44c8-bae9-169b2907d19e/oai/document.pdf","host_type":"repository"},{"url":"https://europepmc.org/articles/PMC6708300","host_type":"Europe_PMC"},{"url":"https://europepmc.org/articles/PMC6708300?pdf=render","host_type":"Europe_PMC"}],"fields_of_study":["Iron Metabolism and Disorders","Erythropoietin and Anemia Treatment","Hemoglobinopathies and Related Disorders"],"mesh_terms":[],"keywords":["Iron deficiency","Iron-deficiency anemia","Iron therapy","Medicine","Anemia","Internal medicine","Iron","Iron Deficiency Anemia (Ida)","Reticulocyte Hemoglobin Equivalent (Ret-he)"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T05:20:05.880015Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}