{"doi":"10.2466/02.13.pr0.110.1.51-62","title":"Decreased Aggressive and Locomotor Behaviors in\n                    <i>Betta Splendens</i>\n                    after Exposure to Fluoxetine","abstract":"<jats:p>The failure of sewage treatment plants to remove pharmaceuticals such as fluoxetine from waste water has become a concern given that these products are being detected in the surface waters of many countries of the world. The effects of fluoxetine in sub-lethal doses on the neural systems and behaviors of aquatic life are worthy of investigation. This study investigated the effects of sub-lethal amounts fluoxetine dissolved in water on the aggressive and locomotor behaviors of 44 male Betta splendens. Fish treated with 705 μg/1 of fluoxetine and 350 μg/1 of fluoxetine generally demonstrated significant decreases in locomotion and number of aggressive attacks compared to 0 μg/1 of fluoxetine (controls) on Days 11 and 19 of drug exposure and persisted for at least 13 days after removal of fluoxetine. Consistent with decreases in the number of aggressive attacks, there was a significant increase in aggression-response time to a perceived intruder for treated males on Days 11 and 19 and persisted for 6 days following removal of fluoxetine. However, the differences in aggressive and locomotor behaviors seen in the fluoxetine-treated groups were indistinguishable from controls three weeks following drug removal.</jats:p>","journal":"Psychological Reports","year":2012,"id":33208,"datarank":3.245940115502913,"base_score":4.304065093204169,"endowment":4.304065093204169,"self_citation_contribution":0.6456097639806255,"citation_network_contribution":2.6003303515222873,"self_endowment_contribution":0.6456097639806255,"citer_contribution":2.6003303515222873,"corpus_percentile":null,"corpus_rank":null,"citation_count":73,"citer_count":73,"citers_with_citation_signal":66,"citers_with_endowment":66,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":174288,"name":"Brian P. Mangan","orcid":null,"position":1,"is_corresponding":false},{"id":174289,"name":"Christine Kodra","orcid":null,"position":2,"is_corresponding":false},{"id":174290,"name":"Linsay Drako","orcid":null,"position":3,"is_corresponding":false},{"id":174291,"name":"Emily Long","orcid":null,"position":4,"is_corresponding":false},{"id":174292,"name":"Holly Simpson","orcid":null,"position":5,"is_corresponding":false},{"id":174287,"name":"Jess G. Kohlert","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.304065093204169,"endowment":4.304065093204169,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"22489377","pmcid":null,"openalex_id":"https://openalex.org/W2029107985","authors":[],"funders":[],"total_grants":0,"fwci":3.257,"citation_percentile":0.91126426,"influential_citations":5,"citation_trend":[{"year":2013,"count":3},{"year":2014,"count":6},{"year":2015,"count":6},{"year":2016,"count":3},{"year":2017,"count":6},{"year":2018,"count":9},{"year":2019,"count":5},{"year":2020,"count":4},{"year":2021,"count":8},{"year":2022,"count":8},{"year":2023,"count":6},{"year":2024,"count":2},{"year":2025,"count":2},{"year":2026,"count":3}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.2466/02.13.PR0.110.1.51-62","host_type":"publisher"},{"url":"https://doi.org/10.2466/02.13.pr0.110.1.51-62","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/22489377","host_type":"repository"}],"fields_of_study":["Pharmaceutical and Antibiotic Environmental Impacts","Fish Ecology and Management Studies","Reproductive biology and impacts on aquatic species","Psychology","Medicine","Biology","Environmental Science","Aggression","Analysis of Variance","Animals","Behavior, Animal","Fishes","Fluoxetine","Follow-Up Studies","Male","Motor Activity","Reaction Time","Selective Serotonin Reuptake Inhibitors","Time Factors"],"mesh_terms":["Aggression","Analysis of Variance","Animals","Behavior, Animal","Fishes","Fluoxetine","Follow-Up Studies","Male","Motor Activity","Reaction Time","Time Factors","Selective Serotonin Reuptake Inhibitors"],"keywords":["Fluoxetine","Aggression","Psychology","Fish <Actinopterygii>","Toxicology","Physiology","Pharmacology","Internal medicine","Medicine","Biology","Developmental psychology","Fishery","Serotonin"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T15:51:33.935023Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}