{"doi":"10.2460/ajvr.1985.46.04.932","title":"Plasma and serum concentrations of phenylbutazone and oxyphenbutazone in racing Thoroughbreds 24 hours after treatment with various dosage regimens","abstract":"<jats:title>SUMMARY</jats:title>\n<jats:p>The plasma and serum concentrations of phenylbutazone (<jats:sc>pbz</jats:sc>) and oxyphenbutazone were measured in 158 Thoroughbred horses after various doses of <jats:sc>pbz</jats:sc> were given. All horses were competing or training at racetracks in various parts of the country. All horses used in the study had not been given <jats:sc>pbz</jats:sc> 24 hours before they were placed on a specific dosage schedule. Samples were collected 24 hours after the last <jats:sc>pbz</jats:sc> administration. Four grams of <jats:sc>pbz</jats:sc> were given daily by stomach tube, paste, or tablet for 3 days. On day 4, 24 hours before sample collection, an <jats:sc>iv</jats:sc> dose of 2 g of <jats:sc>pbz</jats:sc> was given, regardless of the dose and method of administration. The 24-hour <jats:sc>pbz</jats:sc> plasma concentrations were 3.51, 6.13, and 6.40 μg/ml, respectively. After 2 g of <jats:sc>pbz</jats:sc> was administered <jats:sc>iv</jats:sc> daily for 4 days, the plasma <jats:sc>pbz</jats:sc> concentration was 4.16 g/ml; after a single 2-g <jats:sc>iv</jats:sc> administration, the serum concentration was 0.87 g/ml. Concentrations of oxyphenbutazone were 3.35 (stomach tube), 4.29 (paste), 3.60 (tablet), 3.65 (4-day <jats:sc>iv</jats:sc>), and 1.11 g/ml (single <jats:sc>iv</jats:sc>). A significant relationship was not found between the serum and the urinary concentrations at this 24-hour measurement. Split samples sent to various laboratories confirmed the stability of high-performance liquid chromatography as a method of analysis.</jats:p>","journal":"American Journal of Veterinary Research","year":1985,"id":43902,"datarank":0.8470168136091604,"base_score":2.772588722239781,"endowment":2.772588722239781,"self_citation_contribution":0.41588830833596724,"citation_network_contribution":0.43112850527319313,"self_endowment_contribution":0.41588830833596724,"citer_contribution":0.43112850527319313,"corpus_percentile":null,"corpus_rank":null,"citation_count":15,"citer_count":8,"citers_with_citation_signal":7,"citers_with_endowment":7,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":207659,"name":"R. Sams","orcid":null,"position":1,"is_corresponding":false},{"id":207660,"name":"W. Duer","orcid":null,"position":2,"is_corresponding":false},{"id":205195,"name":"T. Tobin","orcid":null,"position":3,"is_corresponding":false},{"id":207661,"name":"C. Woodward","orcid":null,"position":4,"is_corresponding":false},{"id":207662,"name":"J. McDonald","orcid":null,"position":5,"is_corresponding":false},{"id":207658,"name":"L. R. Soma","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.772588722239781,"endowment":2.772588722239781,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"4014842","pmcid":null,"openalex_id":"https://openalex.org/W2409899897","authors":[],"funders":[],"total_grants":0,"fwci":1.849,"citation_percentile":0.86244514,"influential_citations":0,"citation_trend":[{"year":2015,"count":2}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://avmajournals.avma.org/view/journals/ajvr/46/4/ajvr.1985.46.04.932.xml","host_type":"publisher"},{"url":"https://avmajournals.avma.org/downloadpdf/journals/ajvr/46/4/ajvr.1985.46.04.932.xml","host_type":"publisher"},{"url":"https://doi.org/10.2460/ajvr.1985.46.04.932","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/4014842","host_type":"repository"}],"fields_of_study":["Pharmacology and Obesity Treatment","Cardiovascular and exercise physiology","Pharmacological Effects and Assays","Biology","Medicine"],"mesh_terms":["Administration, Oral","Animals","Chromatography, High Pressure Liquid","Dose-Response Relationship, Drug","Horses","Oxyphenbutazone","Phenylbutazone","Regression Analysis","Running"],"keywords":["Oxyphenbutazone","Phenylbutazone","Pharmacology","Chemistry","Medicine","Anesthesia"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-15T04:18:23.358403Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}