{"doi":"10.2460/ajvr.1981.42.05.822","title":"Adrenocortical Suppression in the Dog After a Single Dose of Methylprednisolone Acetate","abstract":"<jats:title>SUMMARY</jats:title>\n<jats:p>Adrenal function was assessed in dogs after intramuscular administration of a single dose of methylprednisolone acetate (<jats:sc>mpa</jats:sc>). Twelve dogs were test challenged with adrenocorticotropic hormone (<jats:sc>acth</jats:sc>) and then assigned randomly to 1 of 3 groups and given <jats:sc>mpa</jats:sc>. Individual groups were test challenged with <jats:sc>acth</jats:sc> 2, 3, or 4 weeks later. All dogs were rechallenged 5 weeks after <jats:sc>mpa</jats:sc> administration. Plasma cortisol concentration was determined by radioimmunoassay. Basal plasma cortisol (time 0) was depressed on weeks 2 and 3, but not on weeks 4 and 5. Adrenal response to <jats:sc>acth</jats:sc> (increment of cortisol change) was suppressed on weeks 2, 4, and 5, but not on week 3. It was concluded that a single dose of <jats:sc>mpa</jats:sc> is capable of altering adrenal cortical function in dogs for at least 5 weeks.</jats:p>","journal":"American Journal of Veterinary Research","year":1981,"id":41070,"datarank":1.0693969475541496,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.6846545439349191,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.6846545439349191,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":9,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":198415,"name":"M. D. Lorenz","orcid":null,"position":1,"is_corresponding":false},{"id":198416,"name":"F. N. Thompson","orcid":null,"position":2,"is_corresponding":false},{"id":198414,"name":"R. J. Kemppainen","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"6266293","pmcid":null,"openalex_id":"https://openalex.org/W85701983","authors":[],"funders":[],"total_grants":0,"fwci":0.6615,"citation_percentile":0.63615561,"influential_citations":0,"citation_trend":[{"year":2013,"count":1},{"year":2014,"count":1},{"year":2015,"count":2},{"year":2024,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://avmajournals.avma.org/view/journals/ajvr/42/5/ajvr.1981.42.05.822.xml","host_type":"publisher"},{"url":"https://avmajournals.avma.org/downloadpdf/journals/ajvr/42/5/ajvr.1981.42.05.822.xml","host_type":"publisher"},{"url":"https://doi.org/10.2460/ajvr.1981.42.05.822","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/6266293","host_type":"repository"}],"fields_of_study":["Adrenal Hormones and Disorders","Thermal Regulation in Medicine","Cancer, Hypoxia, and Metabolism","Medicine","Biology"],"mesh_terms":["Methylprednisolone Acetate","Adrenal Cortex","Adrenal Cortex Function Tests","Adrenal Insufficiency","Adrenocorticotropic Hormone","Animals","Dogs","Female","Hydrocortisone","Male","Methylprednisolone"],"keywords":["Methylprednisolone acetate","Methylprednisolone","Adrenal cortex hormones","Chemistry","Endocrinology","Internal medicine","Medicine","Pharmacology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-12T20:46:32.290611Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}