{"doi":"10.2460/ajvr.1979.40.02.260","title":"Characterization of the Equine Platelet Aggregation Response","abstract":"<jats:title>SUMMARY</jats:title>\n<jats:p>Equine platelet aggregation responses to bovine collagen, adenosine diphosphate (<jats:sc>adp</jats:sc>), serotonin, epinephrine, and arachidonate in a platelet aggregometer were recorded. Equine platelets exhibited irreversible aggregation when incubated with <jats:sc>adp</jats:sc> at a final concentration of 10 <jats:italic>μM</jats:italic> and bovine collagen. A secondary aggregation wave was recorded from platelets from certain horses at final <jats:sc>adp</jats:sc> concentrations of 1 to 5 <jats:italic>μM</jats:italic>. Serotonin and arachidonate induced a weak reversible aggregation response, but a response was not observed following epinephrine addition. Equine platelet aggregation was influenced by concentration of anticoagulant (sodium citrate). Platelet aggregation responses at 37 C were indistinguishable from those recorded at 39 C. Platelet aggregation responses also were altered if the aggregation tests were not performed within 4 hours of blood sample acquisition. An assessment of platelet aggregation from multiple blood samples from the same horse indicated that the procedures described provide a reliable method to assess equine platelet aggregation in vitro.</jats:p>","journal":"American Journal of Veterinary Research","year":1979,"id":30316,"datarank":3.9199865440101007,"base_score":4.04305126783455,"endowment":4.04305126783455,"self_citation_contribution":0.6064576901751826,"citation_network_contribution":3.313528853834918,"self_endowment_contribution":0.6064576901751826,"citer_contribution":3.313528853834918,"corpus_percentile":null,"corpus_rank":null,"citation_count":56,"citer_count":51,"citers_with_citation_signal":47,"citers_with_endowment":47,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":164936,"name":"C. Lindner","orcid":null,"position":1,"is_corresponding":false},{"id":164937,"name":"B. Grant","orcid":null,"position":2,"is_corresponding":false},{"id":164935,"name":"K. M. Meyers","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.04305126783455,"endowment":4.04305126783455,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"464363","pmcid":null,"openalex_id":"https://openalex.org/W2460641595","authors":[],"funders":[],"total_grants":0,"fwci":0.3328,"citation_percentile":0.64927251,"influential_citations":0,"citation_trend":[{"year":2013,"count":5},{"year":2016,"count":1},{"year":2017,"count":1},{"year":2021,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://avmajournals.avma.org/view/journals/ajvr/40/2/ajvr.1979.40.02.260.xml","host_type":"publisher"},{"url":"https://avmajournals.avma.org/downloadpdf/journals/ajvr/40/2/ajvr.1979.40.02.260.xml","host_type":"publisher"},{"url":"https://doi.org/10.2460/ajvr.1979.40.02.260","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/464363","host_type":"repository"}],"fields_of_study":["Antiplatelet Therapy and Cardiovascular Diseases","Pharmacology and Obesity Treatment","Analytical Methods in Pharmaceuticals","Medicine","Biology"],"mesh_terms":["Adenosine Diphosphate","Animals","Arachidonic Acids","Collagen","Epinephrine","Horses","Platelet Aggregation","Serotonin","Temperature","Time Factors"],"keywords":["Platelet","Platelet aggregation","Adenosine diphosphate","Epinephrine","Chemistry","Serotonin","Horse","Biochemistry","Internal medicine","Endocrinology","Medicine","Biology","Receptor"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Clean water and sanitation"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-06-09T02:14:56.313040Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}