{"doi":"10.2450/2023.0229-22","title":"Unknown","abstract":null,"journal":null,"year":null,"id":607490,"datarank":0.16479184330021646,"base_score":1.0986122886681096,"endowment":1.0986122886681096,"self_citation_contribution":0.16479184330021646,"citation_network_contribution":0.0,"self_endowment_contribution":0.16479184330021646,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Benefits of hypoxic storage of red blood cells.","abstract":"Erythrocytes or red blood cells (RBCs) are unique cells that supply sufficient oxygen to tissues to fuel oxidative phosphorylation for efficient energy production.RBCs survive in the human circulation system for approximately 120 days.During this time, they accumulate oxidative damage and are promptly removed by the reticuloendothelial system.Packed RBC storage in the blood bank is a logistic necessity, making approximately 100 million blood units available for transfusion every year worldwide.However, as RBCs are stored up to 42 days under refrigerated conditions (+4 o C), whether after leukoreduction or not, they accumulate a series of biochemical and morphological changes, collectively referred to as the storage lesion 1 .The erythrocyte storage lesion is affected by biological (the genetic profile such as sex, G6PD, Hb traits) and environmental (donor age, diet, and smoking habits) factors.Such alterations are primarily driven by oxidant stress 2 and target redox sensitive metabolic enzymes 3 upstream to 2,3-diphosphoglycerate (DPG) and adenosine triphosphate (ATP) synthesis, thus resulting in the depletion of these metabolites.This phenomenon in turn alters RBC oxygen kinetics, due to the role of DPG and ATP in the modulation of hemoglobin allostery 4 .The RBC storage lesion results in decreased circulation and function of transfused erythrocytes.Over the years, the Zimring lab has pioneered novel murine models of blood storage, the scope of which has been to show that genetic factors contribute to the heterogeneity of the onset and severity of the RBC storage lesion, ultimately reducing the capacity of the stored erythrocyte to circulate after transfusion as a function of redox system activity 5 .Murine models can check for genetic or environmental factors, and much interventional research can be carried out in mice that is neither technically feasible nor ethical in humans.In parallel, studies in humans, which had received fresh impetus from the work of Bitensky and Yoshida 6 , have posited that storage of RBC under oxygen-depleted conditions (hypoxia to anerobiosis) contributes to a Fenton and Haber-Weiss reaction, to the extent that these iron-dependent reactions fuel the generation of reactive oxygen species in the stored RBC 7 .Since these seminal observations, follow-up studies from the D'Alessandro lab have proved that hypoxic storage of RBCs reduces oxidation of glycolytic enzymes 8 , hemoglobin at functional residues 9 , decreases purine breakdown and deamination 10 , preserves RBC morphology 11 and ultimately results in improved metabolic phenotypes and increased post-transfusion recovery 12 .Some of these benefits of hypoxic storage are not necessarily completely dependent on the prevention of oxygen radical formation.Indeed, they may, at least in part, be explained by the activating effect of alkalinization on 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Preservation"],"mesh_terms":["Hypoxia","Blood Preservation","Erythrocytes","Humans"],"keywords":["Blood preservation","Medicine","Intensive care medicine","Andrology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T06:29:28.137770Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}