{"doi":"10.2337/figshare.19196288","title":"Effects of Intensive Lifestyle Intervention on All-Cause Mortality in Older Adults With Type 2 Diabetes and Overweight/Obesity: Results From the Look AHEAD Study","abstract":"Background. Look AHEAD, a randomized trial comparing intensive lifestyle intervention (ILI) and diabetes support and education (DSE) (control) in 5145 individuals with overweight/obesity and type 2 diabetes, found no significant differences in all-cause or cardiovascular mortality or morbidity during 9.6 (median) years of intervention. Participants in ILI who lost ≥10% at 1 year had lower risk of composite cardiovascular outcomes relative to DSE. <p>Objective: Since effects of ILI may take many years to emerge, we conducted intent-to-treat analyses comparing mortality in ILI over 16.7 years (9.6 year of intervention and then observation) to DSE. In a secondary exploratory analysis, we compared mortality by magnitude of weight loss in ILI relative to DSE.</p> <p>Methods. Primary outcome was all-cause mortality from randomization to 16.7 years. Other outcomes included cause-specific mortality, interactions by sub-groups (age, sex, race/ethnicity, CVD history) and an exploratory analysis by magnitude of weight loss in ILI vs DSE as reference. Analyses used proportional hazards regression and likelihood ratio. </p> <p>Results. The incidence of all-cause mortality did not differ significantly in ILI and DSE (549 and 589 participants respectively); HR = 0.91; 95% CI (0.81,1.02), p=0.11. There were no significant differences between treatments in cause-specific mortality or within prespecified subgroups. ILI participants who lost ≥10% at 1 year had a 21% reduced risk of mortality (HR=0.79, CI 0.67,0.94, p=0.007) relative to DSE.</p> <p>Conclusions. ILI focused on weight loss did not significantly affect mortality risk. However, ILI participants who lost ≥10% had reduced mortality relative to DSE. </p>","journal":null,"year":2022,"id":301757,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":2,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7063,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":262997,"name":"Jeanne M. Clark","orcid":"0000-0003-1194-0092","position":1,"is_corresponding":false},{"id":86124,"name":"Edward W. Gregg","orcid":"0000-0003-2381-6822","position":2,"is_corresponding":false},{"id":260521,"name":"Stephen B. Kritchevsky","orcid":"0000-0003-3336-6781","position":3,"is_corresponding":false},{"id":245367,"name":"Cora E. Lewis","orcid":"0000-0002-2301-5796","position":4,"is_corresponding":false},{"id":400005,"name":"F. Xavier Pi‐Sunyer","orcid":"0000-0003-2207-2008","position":5,"is_corresponding":false},{"id":295972,"name":"David M. Reboussin","orcid":"0000-0003-1309-2189","position":6,"is_corresponding":false},{"id":110110,"name":"Thomas A. Wadden","orcid":"0000-0002-0438-4609","position":7,"is_corresponding":false},{"id":305437,"name":"Lynne E. Wagenknecht","orcid":"0000-0002-9980-0889","position":8,"is_corresponding":false},{"id":367546,"name":"Susan Z. Yanovski","orcid":"0000-0002-6843-1670","position":9,"is_corresponding":false},{"id":367544,"name":"Rena R. Wing","orcid":"0000-0002-0918-8252","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T00:32:06.309890Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}