{"doi":"10.2337/dci20-0080","title":"Response to Comment on Piccinini and Bergman The Measurement of Insulin Clearance. Diabetes Care 2020;43:2296–2302","abstract":"We thank Dr. Gastadelli and colleagues for their interest in our review article (1) and their comments (2) on the limitations of different approaches to assessing insulin clearance in humans and putative limitations of the hypothesis (3) that lower insulin clearance might cause type 2 diabetes (T2D). In fact, many of their comments relate to a series of articles from our group, and in addition to the article they refer to (1), several others (4–6) are also relevant to their comments.\n\nConcerning the Polidori/Bergman model (4), they are correct that the approach used by Polidori et al. (4) assumes either linear or saturable hepatic insulin extraction and chooses the model that best fits the data. We believe these are reasonable assumptions and that there is little support for the claim by Gastadelli et al. (2) that a saturable model of hepatic insulin extraction is not justified based on experimental data. The articles they cite claiming that hepatic insulin extraction does not reach saturability until insulin concentrations are in the 300–500 mU/L range are based on comparisons between groups of …","journal":"Diabetes Care","year":2020,"id":87893,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9596,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":234130,"name":"Francesca Piccinini","orcid":null,"position":1,"is_corresponding":false},{"id":21855,"name":"Richard N. Bergman","orcid":"0000-0003-1539-4471","position":0,"is_corresponding":true}],"reference_count":10,"raw_metadata":null,"created_at":"2026-07-18T22:00:29.831859Z","pmid":"33972319","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}