{"doi":"10.2337/dc23-1681","title":"Longitudinal Assessment of Pancreas Volume by MRI Predicts Progression to Stage 3 Type 1 Diabetes","abstract":"OBJECTIVE: This multicenter prospective cohort study compared pancreas volume as assessed by MRI, metabolic scores derived from oral glucose tolerance testing (OGTT), and a combination of pancreas volume and metabolic scores for predicting progression to stage 3 type 1 diabetes (T1D) in individuals with multiple diabetes-related autoantibodies. RESEARCH DESIGN AND METHODS: Pancreas MRI was performed in 65 multiple autoantibody-positive participants enrolled in the Type 1 Diabetes TrialNet Pathway to Prevention study. Prediction of progression to stage 3 T1D was assessed using pancreas volume index (PVI), OGTT-derived Index60 score and Diabetes Prevention Trial-Type 1 Risk Score (DPTRS), and a combination of PVI and DPTRS. RESULTS: PVI, Index60, and DPTRS were all significantly different at study entry in 11 individuals who subsequently experienced progression to stage 3 T1D compared with 54 participants who did not experience progression (P < 0.005). PVI did not correlate with metabolic testing across individual study participants. PVI declined longitudinally in the 11 individuals diagnosed with stage 3 T1D, whereas Index60 and DPTRS increased. The area under the receiver operating characteristic curve for predicting progression to stage 3 from measurements at study entry was 0.76 for PVI, 0.79 for Index60, 0.79 for DPTRS, and 0.91 for PVI plus DPTRS. CONCLUSIONS: These findings suggest that measures of pancreas volume and metabolism reflect distinct components of risk for developing stage 3 type 1 diabetes and that a combination of these measures may provide superior prediction than either alone.","journal":"Diabetes Care","year":2023,"id":329121,"datarank":0.6663438349150109,"base_score":3.091042453358316,"endowment":3.091042453358316,"self_citation_contribution":0.4636563680037475,"citation_network_contribution":0.20268746691126344,"self_endowment_contribution":0.4636563680037475,"citer_contribution":0.20268746691126344,"corpus_percentile":null,"corpus_rank":null,"citation_count":21,"citer_count":14,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.7404,"is_data_producer":true,"deposit_databanks":{"figshare":["10.2337/figshare.24713238"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":310411,"name":"J. 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Valencia","orcid":null,"position":9,"is_corresponding":false},{"id":1052360,"name":"Demetra Reyes","orcid":null,"position":10,"is_corresponding":false},{"id":1052361,"name":"Brenna Hammel","orcid":null,"position":11,"is_corresponding":false},{"id":374833,"name":"William E. Russell","orcid":"0000-0001-7609-0434","position":12,"is_corresponding":false},{"id":230363,"name":"Louis H. Philipson","orcid":"0000-0002-2208-3607","position":13,"is_corresponding":false},{"id":1052362,"name":"Michaela Waibel","orcid":null,"position":14,"is_corresponding":false},{"id":921014,"name":"Thomas W. H. Kay","orcid":"0000-0002-7273-2556","position":15,"is_corresponding":false},{"id":581252,"name":"Helen E. Thomas","orcid":"0000-0001-6604-6640","position":16,"is_corresponding":false},{"id":251699,"name":"Siri Atma W. Greeley","orcid":"0000-0002-0741-3567","position":17,"is_corresponding":false},{"id":96015,"name":"Andrea K. 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