{"doi":"10.2337/dc23-0696","title":"Effect of Conventional Lifestyle Interventions on Type 2 Diabetes Incidence by Glucose-Defined Prediabetes Phenotype: An Individual Participant Data Meta-analysis of Randomized Controlled Trials","abstract":"OBJECTIVE: To examine whether the effect of conventional lifestyle interventions on type 2 diabetes incidence differs by glucose-defined prediabetes phenotype. RESEARCH DESIGN AND METHODS: We searched multiple databases until 1 April 2023 for randomized controlled trials that recruited people with isolated impaired fasting glucose (i-IFG), isolated impaired glucose tolerance (i-IGT), and impaired fasting glucose plus impaired glucose tolerance (IFG+IGT). Individual participant data were pooled from relevant trials and analyzed through random-effects models with use of the within-trial interactions approach. RESULTS: Four trials with 2,794 participants (mean age 53.0 years, 60.7% men) were included: 1,240 (44.4%), 796 (28.5%), and 758 (27.1%) had i-IFG, i-IGT, and IFG+IGT, respectively. After a median of 2.5 years, the pooled hazard ratio for diabetes incidence in i-IFG was 0.97 (95% CI 0.66, 1.44), i-IGT 0.65 (0.44, 0.96), and IFG+IGT 0.51 (0.38, 0.68; Pinteraction = 0.01). CONCLUSIONS: Conventional lifestyle interventions reduced diabetes incidence in people with IGT (with or without IFG) but not in those with i-IFG.","journal":"Diabetes Care","year":2023,"id":318545,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":64,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.8715,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":236347,"name":"Kamlesh Khunti","orcid":"0000-0003-2343-7099","position":1,"is_corresponding":false},{"id":245134,"name":"K.M. Venkat Narayan","orcid":"0000-0001-8621-5405","position":2,"is_corresponding":false},{"id":38951,"name":"Viswanathan Mohan","orcid":"0000-0001-5038-6210","position":3,"is_corresponding":false},{"id":257817,"name":"Melanie J. Davies","orcid":"0000-0002-9987-9371","position":4,"is_corresponding":false},{"id":230824,"name":"Thomas Yates","orcid":"0000-0002-5724-5178","position":5,"is_corresponding":false},{"id":332274,"name":"Brian Oldenburg","orcid":"0000-0002-7712-5413","position":6,"is_corresponding":false},{"id":1025859,"name":"Kavumpurathu R. Thankappan","orcid":"0000-0002-4536-2684","position":7,"is_corresponding":false},{"id":393401,"name":"Robyn J. Tapp","orcid":"0000-0002-8553-2684","position":8,"is_corresponding":false},{"id":1025860,"name":"Ram Bajpai","orcid":"0000-0002-1227-2703","position":9,"is_corresponding":false},{"id":344913,"name":"Ranjit Mohan Anjana","orcid":"0000-0002-4843-1374","position":10,"is_corresponding":false},{"id":337640,"name":"Mary Beth Weber","orcid":"0000-0002-2804-3948","position":11,"is_corresponding":false},{"id":22946,"name":"Mohammed K. Ali","orcid":"0000-0001-7266-2503","position":12,"is_corresponding":false},{"id":7886,"name":"Jonathan E. Shaw","orcid":"0000-0002-6187-2203","position":13,"is_corresponding":false},{"id":48682,"name":"Thirunavukkarasu Sathish","orcid":null,"position":0,"is_corresponding":true}],"reference_count":21,"raw_metadata":null,"created_at":"2026-07-19T01:07:01.300821Z","pmid":"37650824","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}