{"doi":"10.2337/dc23-0622","title":"Type 1 Diabetes Genetic Risk Score Differentiates Subgroups of Ketosis-Prone Diabetes","abstract":"OBJECTIVE: To determine whether genetic risk for type 1 diabetes (T1D) differentiates the four Aβ subgroups of ketosis-prone diabetes (KPD), where A+ and A- define the presence or absence of islet autoantibodies and β+ and β- define the presence or absence of β-cell function. RESEARCH DESIGN AND METHODS: We compared T1D genetic risk scores (GRS) of patients with KPD across subgroups, race/ethnicity, β-cell function, and glycemia. RESULTS: Among 426 patients with KPD (54% Hispanic, 31% African American, 11% White), rank order of GRS was A+β- > A+β+ = A-β- > A-β+. GRS of A+β- KPD was lower than that of a T1D cohort, and GRS of A-β+ KPD was higher than that of a type 2 diabetes cohort. GRS was lowest among African American patients, with a similar distribution across KPD subgroups. CONCLUSIONS: T1D genetic risk delineates etiologic differences among KPD subgroups. Patients with A+β- KPD have the highest and those with A-β+ KPD the lowest GRS.","journal":"Diabetes Care","year":2023,"id":365863,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":6,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9595,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1121701,"name":"Surya N. Mulukutla","orcid":"0000-0002-0447-0638","position":1,"is_corresponding":false},{"id":512150,"name":"Christiane S. Hampe","orcid":"0000-0001-9111-6671","position":2,"is_corresponding":false},{"id":944220,"name":"Ruchi Gaba","orcid":"0000-0001-5361-3191","position":3,"is_corresponding":false},{"id":1122123,"name":"Nalini Ram","orcid":null,"position":4,"is_corresponding":false},{"id":22004,"name":"Michael N. Weedon","orcid":"0000-0002-6174-6135","position":5,"is_corresponding":false},{"id":249639,"name":"Richard A. Oram","orcid":"0000-0003-3581-8980","position":6,"is_corresponding":false},{"id":249640,"name":"Ashok Balasubramanyam","orcid":"0000-0003-2093-5201","position":7,"is_corresponding":false},{"id":1121700,"name":"Deborah Osafehinti","orcid":"0000-0001-7721-7249","position":0,"is_corresponding":true}],"reference_count":20,"raw_metadata":null,"created_at":"2026-07-19T01:14:50.885797Z","pmid":"37506364","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}