{"doi":"10.2337/dc22-1359","title":"Interaction Between Dietary Iron Intake and Genetically Determined Iron Overload: Risk of Islet Autoimmunity and Progression to Type 1 Diabetes in the TEDDY Study","abstract":"OBJECTIVE: To examine whether iron intake and genetically determined iron overload interact in predisposing to the development of childhood islet autoimmunity (IA) and type 1 diabetes (T1D). RESEARCH DESIGN AND METHODS: In The Environmental Determinants of Diabetes in the Young (TEDDY) study, 7,770 genetically high-risk children were followed from birth until the development of IA and progression to T1D. Exposures included energy-adjusted iron intake in the first 3 years of life and a genetic risk score (GRS) for increased circulating iron. RESULTS: We found a U-shaped association between iron intake and risk of GAD antibody as the first autoantibody. In children with GRS ≥2 iron risk alleles, high iron intake was associated with an increased risk of IA, with insulin as first autoantibody (adjusted hazard ratio 1.71 [95% CI 1.14; 2.58]) compared with moderate iron intake. CONCLUSIONS: Iron intake may alter the risk of IA in children with high-risk HLA haplogenotypes.","journal":"Diabetes Care","year":2023,"id":361810,"datarank":0.3734662208539385,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.04388253425350551,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.04388253425350551,"corpus_percentile":51.89139011371548,"corpus_rank":6220,"citation_count":8,"citer_count":4,"citers_with_citation_signal":3,"citers_with_endowment":3,"datacite_reuse_total":0,"is_dataset":true,"is_dataset_confidence":0.5431,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":414041,"name":"Xiang Liu","orcid":"0000-0002-8451-3465","position":1,"is_corresponding":false},{"id":743629,"name":"Yachana Kataria","orcid":"0000-0002-6249-7134","position":2,"is_corresponding":false},{"id":354421,"name":"Thomas Mandrup‐Poulsen","orcid":"0000-0002-3215-9273","position":3,"is_corresponding":false},{"id":1114583,"name":"Simranjeet Kaur","orcid":"0000-0003-0490-1028","position":4,"is_corresponding":false},{"id":500513,"name":"Ulla Uusitalo","orcid":"0000-0001-9132-7727","position":5,"is_corresponding":false},{"id":344341,"name":"Suvi Μ. 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