{"doi":"10.2337/dc22-0824","title":"Impact of a Novel Diabetes Prevention Intervention for Early Slow Weight Loss Responders Among Adults With Prediabetes: An Adaptive Trial","abstract":"OBJECTIVE: Some people are slower to respond during lifestyle interventions. An adaptive \"rescue\" intervention may improve outcomes among slow responders. The impact of a worksite rescue intervention for early slow responders was evaluated. RESEARCH DESIGN AND METHODS: Employees ≥21 years old with prediabetes were stratified to intervention using a 2.5% weight loss (%WL) threshold at week 5. Outcomes were assessed at baseline and at 4 months using mixed-effect and linear regression models. RESULTS: Significant improvement occurred in mean %WL, glycemia, total cholesterol, and triglycerides in the standard compared with the adaptive (Group Lifestyle Balance Plus [GLB+]) intervention (all P≤ 0.01). However, GLB+ participants also experienced a significant reduction in %WL and glycemia (all P < 0.01). The %WL at week 5 significantly predicted %WL at 4 months (P < 0.0001). The between-group difference of 4-month %WL was not significant for someone achieving 2.5%WL at week 5. CONCLUSIONS: Diabetes prevention programs should consider weight loss success following 1 month of treatment and offer a rescue intervention to early slow weight loss responders.","journal":"Diabetes Care","year":2022,"id":272045,"datarank":0.4183412842813061,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.033598880662075545,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.033598880662075545,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":6,"citers_with_citation_signal":2,"citers_with_endowment":2,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9572,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT03382873"],"figshare":["10.2337/figshare.20388144"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":274562,"name":"Haikady N. Nagaraja","orcid":"0000-0001-8896-0804","position":1,"is_corresponding":false},{"id":444212,"name":"Jennifer S. Cheavens","orcid":"0000-0002-3778-9346","position":2,"is_corresponding":false},{"id":937964,"name":"Kentaro Fujita","orcid":"0000-0002-3527-6002","position":3,"is_corresponding":false},{"id":937965,"name":"Sophie A. Lazarus","orcid":"0000-0003-0434-2422","position":4,"is_corresponding":false},{"id":937963,"name":"Carla K. Miller","orcid":"0000-0002-1002-7288","position":0,"is_corresponding":true}],"reference_count":16,"raw_metadata":null,"created_at":"2026-07-19T00:27:43.806977Z","pmid":"36041053","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}