{"doi":"10.2337/dc21-2517","title":"Changes in Circulating miR-375-3p and Improvements in Visceral and Hepatic Fat Contents in Response to Lifestyle Interventions: The CENTRAL Trial","abstract":"OBJECTIVE: To investigate whether changes in circulating levels of pancreatic islet-related miRNA-375 (miR-375) are related to improved visceral and intrahepatic fat accumulation. RESEARCH DESIGN AND METHODS: This study included adults with abdominal obesity from an 18-month weight loss lifestyle intervention trial. Circulating miR-375-3p was measured at baseline and 18 months. MRI was performed (n = 139) to assess 18-month changes in abdominal and intrahepatic fat depots. RESULTS: Circulating miR-375-3p was related to fasting insulin and insulin resistance in participants with prediabetes. After the interventions, there was a significant increase of miR-375-3p (P < 0.001). Greater increase in miR-375-3p was associated with greater reductions of visceral (P = 0.024) and deep subcutaneous (P < 0.001) adipose tissues and intrahepatic fat content (P = 0.012). CONCLUSIONS: Increases in circulating miR-375-3p were associated with visceral and intrahepatic fat reduction. Changes in circulating pancreatic islet-related miR-375-3p may be linked to improved diabetogenic fat depots during weight loss lifestyle interventions.","journal":"Diabetes Care","year":2022,"id":264173,"datarank":0.46651951425355226,"base_score":2.5649493574615367,"endowment":2.5649493574615367,"self_citation_contribution":0.38474240361923057,"citation_network_contribution":0.08177711063432168,"self_endowment_contribution":0.38474240361923057,"citer_contribution":0.08177711063432168,"corpus_percentile":null,"corpus_rank":null,"citation_count":12,"citer_count":10,"citers_with_citation_signal":5,"citers_with_endowment":5,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9191,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01530724"],"figshare":["10.2337/figshare.19748788"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":614306,"name":"Knut Krohn","orcid":"0000-0001-8110-1273","position":1,"is_corresponding":false},{"id":247809,"name":"Anat Yaskolka Meir","orcid":"0000-0002-2480-3751","position":2,"is_corresponding":false},{"id":913350,"name":"Xuan Wang","orcid":"0000-0002-6588-2951","position":3,"is_corresponding":false},{"id":912772,"name":"Stefanie Ziesche","orcid":null,"position":4,"is_corresponding":false},{"id":247819,"name":"Uta Ceglarek","orcid":"0000-0002-4034-5535","position":5,"is_corresponding":false},{"id":21736,"name":"Matthias Blüher","orcid":"0000-0003-0208-2065","position":6,"is_corresponding":false},{"id":912294,"name":"Maria Keller","orcid":"0000-0003-4026-8530","position":7,"is_corresponding":false},{"id":22047,"name":"Péter Kovács","orcid":"0000-0002-0290-5423","position":8,"is_corresponding":false},{"id":247821,"name":"Iris Shai","orcid":"0000-0001-9050-4605","position":9,"is_corresponding":false},{"id":21926,"name":"Lu Qi","orcid":"0000-0002-8041-7791","position":10,"is_corresponding":false},{"id":256514,"name":"Yoriko Heianza","orcid":"0000-0002-0957-9309","position":0,"is_corresponding":true}],"reference_count":15,"raw_metadata":null,"created_at":"2026-07-19T00:26:37.567338Z","pmid":"35657082","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}