{"doi":"10.2337/db23-0232","title":"Polygenic Risk for Type 2 Diabetes in African Americans","abstract":"African Americans (AAs) have been underrepresented in polygenic risk score (PRS) studies. Here, we integrated genome-wide data from multiple observational studies on type 2 diabetes (T2D), encompassing a total of 101,987 AAs, to train and optimize an AA-focused T2D PRS (PRSAA), using a Bayesian polygenic modeling method. We further tested the score in three independent studies with a total of 7,275 AAs and compared the PRSAA with other published scores. Results show that a 1-SD increase in the PRSAA was associated with 40-60% increase in the odds of T2D (odds ratio [OR] 1.60, 95% CI 1.37-1.88; OR 1.40, 95% CI 1.16-1.70; and OR 1.45, 95% CI 1.30-1.62) across three testing cohorts. These models captured 1.0-2.6% of the variance (R2) in T2D on the liability scale. The positive predictive values for three calculated score thresholds (the top 2%, 5%, and 10%) ranged from 14 to 35%. The PRSAA, in general, performed similarly to existing T2D PRS. The need remains for larger data sets to continue to evaluate the utility of within-ancestry scores in the AA population.","journal":"Diabetes","year":2024,"id":442067,"datarank":0.40387545245706613,"base_score":2.1972245773362196,"endowment":2.1972245773362196,"self_citation_contribution":0.32958368660043297,"citation_network_contribution":0.07429176585663319,"self_endowment_contribution":0.32958368660043297,"citer_contribution":0.07429176585663319,"corpus_percentile":null,"corpus_rank":null,"citation_count":8,"citer_count":7,"citers_with_citation_signal":4,"citers_with_endowment":4,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9467,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2024-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":107803,"name":"Tian Ge","orcid":"0000-0003-4785-4444","position":1,"is_corresponding":false},{"id":538011,"name":"Amit Patki","orcid":"0000-0003-2140-3856","position":2,"is_corresponding":false},{"id":708126,"name":"Vinodh Srinivasasainagendra","orcid":null,"position":3,"is_corresponding":false},{"id":686090,"name":"Nicole D. Armstrong","orcid":"0000-0002-6483-4560","position":4,"is_corresponding":false},{"id":546075,"name":"Brittney H. Davis","orcid":"0000-0001-6717-2649","position":5,"is_corresponding":false},{"id":393081,"name":"Alana Jones","orcid":"0000-0003-3827-2426","position":6,"is_corresponding":false},{"id":649101,"name":"Emma Perez","orcid":null,"position":7,"is_corresponding":false},{"id":11236,"name":"Lauren Stalbow","orcid":"0000-0002-8907-1467","position":8,"is_corresponding":false},{"id":381639,"name":"Matthew S. Lebo","orcid":"0000-0002-9733-5207","position":9,"is_corresponding":false},{"id":24490,"name":"Eimear E. Kenny","orcid":"0000-0001-9198-759X","position":10,"is_corresponding":false},{"id":1082,"name":"Ruth J. F. Loos","orcid":"0000-0002-8532-5087","position":11,"is_corresponding":false},{"id":90080,"name":"Maggie C. Y. Ng","orcid":"0000-0002-4133-2007","position":12,"is_corresponding":false},{"id":104618,"name":"Jordan W. Smoller","orcid":"0000-0002-0381-6334","position":13,"is_corresponding":false},{"id":1092,"name":"James B. Meigs","orcid":"0000-0002-2439-2657","position":14,"is_corresponding":false},{"id":515141,"name":"Leslie A. Lange","orcid":"0000-0002-8077-4975","position":15,"is_corresponding":false},{"id":218345,"name":"Elizabeth W. Karlson","orcid":"0000-0001-5455-7443","position":16,"is_corresponding":false},{"id":386043,"name":"Nita A. Limdi","orcid":"0000-0002-4672-8406","position":17,"is_corresponding":false},{"id":25027,"name":"Hemant K. Tiwari","orcid":null,"position":18,"is_corresponding":false},{"id":24975,"name":"Marguerite R. Irvin","orcid":"0000-0002-1442-2023","position":0,"is_corresponding":true}],"reference_count":32,"raw_metadata":{"citation_network_status":"fetched"},"created_at":"2026-07-19T02:01:15.932178Z","pmid":"38470993","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}