{"doi":"10.2337/db22-0399","title":"Effects of GLP-1 and GIP on Islet Function in Glucose-Intolerant, Pancreatic-Insufficient Cystic Fibrosis","abstract":"Impaired insulin and incretin secretion underlie abnormal glucose tolerance (AGT) in pancreatic insufficient cystic fibrosis (PI-CF). Whether the incretin hormones glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP) can enhance pancreatic islet function in cystic fibrosis (CF) is not known. We studied 32 adults with PI-CF and AGT randomized to receive either GLP-1 (n = 16) or GIP (n = 16) during glucose-potentiated arginine (GPA) testing of islet function on two occasions, with either incretin or placebo infused, in a randomized, double-blind, cross-over fashion. Another four adults with PI-CF and normal glucose tolerance (NGT) and four matched control participants without CF underwent similar assessment with GIP. In PI-CF with AGT, GLP-1 substantially augmented second-phase insulin secretion but without effect on the acute insulin response to GPA or the proinsulin secretory ratio (PISR), while GIP infusion did not enhance second-phase or GPA-induced insulin secretion but increased the PISR. GIP also did not enhance second-phase insulin in PI-CF with NGT but did so markedly in control participants without CF controls. These data indicate that GLP-1, but not GIP, augments glucose-dependent insulin secretion in PI-CF, supporting the likelihood that GLP-1 agonists could have therapeutic benefit in this population. Understanding loss of GIP's insulinotropic action in PI-CF may lead to novel insights into diabetes pathogenesis.","journal":"Diabetes","year":2022,"id":253583,"datarank":1.1217324950364596,"base_score":3.1354942159291497,"endowment":3.1354942159291497,"self_citation_contribution":0.47032413238937254,"citation_network_contribution":0.651408362647087,"self_endowment_contribution":0.47032413238937254,"citer_contribution":0.651408362647087,"corpus_percentile":null,"corpus_rank":null,"citation_count":22,"citer_count":18,"citers_with_citation_signal":13,"citers_with_endowment":13,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9404,"is_data_producer":true,"deposit_databanks":{"ClinicalTrials.gov":["NCT01851694"],"figshare":["10.2337/figshare.20213744"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":672101,"name":"Amy J. Peleckis","orcid":"0000-0002-3772-2782","position":1,"is_corresponding":false},{"id":673036,"name":"Jack N. Eiel","orcid":null,"position":2,"is_corresponding":false},{"id":900167,"name":"Kathryn Gallagher","orcid":null,"position":3,"is_corresponding":false},{"id":900168,"name":"Andriana Doliba","orcid":null,"position":4,"is_corresponding":false},{"id":899533,"name":"Abigail Tami","orcid":"0000-0003-4273-0995","position":5,"is_corresponding":false},{"id":899534,"name":"Anneliese J. Flatt","orcid":"0000-0003-4315-5136","position":6,"is_corresponding":false},{"id":542261,"name":"Diva D. De León","orcid":"0000-0003-1225-8087","position":7,"is_corresponding":false},{"id":500491,"name":"Denis Hadjiliadis","orcid":"0000-0002-8602-9503","position":8,"is_corresponding":false},{"id":500489,"name":"Saba Sheikh","orcid":"0000-0002-4164-6663","position":9,"is_corresponding":false},{"id":341656,"name":"Darko Stefanovski","orcid":"0000-0002-4654-0569","position":10,"is_corresponding":false},{"id":331682,"name":"Robert Gallop","orcid":"0000-0001-9986-2994","position":11,"is_corresponding":false},{"id":226899,"name":"David A. D’Alessio","orcid":"0000-0003-4155-4870","position":12,"is_corresponding":false},{"id":383735,"name":"Ronald C. Rubenstein","orcid":"0000-0002-3138-4006","position":13,"is_corresponding":false},{"id":32955,"name":"Andrea Kelly","orcid":"0000-0003-1724-9868","position":14,"is_corresponding":false},{"id":231672,"name":"Michael R. Rickels","orcid":"0000-0002-9253-838X","position":15,"is_corresponding":false},{"id":672102,"name":"Sarah C. Nyirjesy","orcid":"0000-0001-7304-7211","position":0,"is_corresponding":true}],"reference_count":51,"raw_metadata":null,"created_at":"2026-07-19T00:24:59.596040Z","pmid":"35796669","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}