{"doi":"10.2337/db21-0754","title":"MRI Metrics of Cerebral Endothelial Cell–Derived Exosomes for the Treatment of Cognitive Dysfunction Induced in Aging Rats Subjected to Type 2 Diabetes","abstract":"Ongoing neurovascular dysfunction contributes to type 2 diabetes mellitus (T2DM)-induced cognitive deficits. However, it is not known whether early post onset of T2DM interventions may reduce evolving neurovascular dysfunction and thereby lead to diminution of T2DM-induced cognitive deficits. Using multiple MRI metrics, we evaluated neurovascular changes in T2DM rats treated with exosomes derived from cerebral endothelial cells (CEC-Exos). Two months after induction of T2DM in middle-aged male rats by administration of streptozotocin nicotinamide, rats were randomly treated with CEC-Exos twice weekly or saline for 4 consecutive weeks (n = 10/group). MRI measurements were performed at the end of the treatment, which included cerebral blood flow (CBF), contrast-enhanced T1-weighted imaging, and relaxation time constants T1 and T2. MRI analysis showed that compared with controls, the CEC-Exo-treated T2DM rats exhibited significant elevation of T2 and CBF in white matter and significant augmentation of T1 and reduction of blood-brain barrier permeability in gray matter. In the hippocampus, CEC-Exo treatment significantly increased T1 and CBF. Furthermore, CEC-Exo treatment significantly reduced T2DM-induced cognitive deficits measured by the Morris water maze and odor recognition tests. Collectively, our corresponding MRI data demonstrate that treatment of T2DM rats with CEC-Exos robustly reduced neurovascular dysfunction in gray and white matter and the hippocampus.","journal":"Diabetes","year":2022,"id":266387,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":9,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9573,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2022-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":348382,"name":"Lian Li","orcid":"0000-0003-0097-1184","position":1,"is_corresponding":false},{"id":348384,"name":"Li Zhang","orcid":"0000-0002-8583-3452","position":2,"is_corresponding":false},{"id":337609,"name":"Michael Chopp","orcid":"0000-0002-1948-4493","position":3,"is_corresponding":false},{"id":241350,"name":"Esmaeil Davoodi‐Bojd","orcid":"0000-0003-3122-3891","position":4,"is_corresponding":false},{"id":885883,"name":"Qingjiang Li","orcid":"0000-0002-1491-4757","position":5,"is_corresponding":false},{"id":926073,"name":"Chao Li","orcid":"0000-0001-9629-9219","position":6,"is_corresponding":false},{"id":926074,"name":"Min Wei","orcid":"0000-0003-0237-7955","position":7,"is_corresponding":false},{"id":462126,"name":"Zhenggang Zhang","orcid":"0000-0002-7196-7644","position":8,"is_corresponding":false},{"id":348386,"name":"Quan Jiang","orcid":"0000-0001-7908-4443","position":9,"is_corresponding":false},{"id":348383,"name":"Guangliang Ding","orcid":"0000-0003-1286-5901","position":0,"is_corresponding":true}],"reference_count":50,"raw_metadata":null,"created_at":"2026-07-19T00:26:54.081997Z","pmid":"35175337","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}