{"doi":"10.2337/db20-0296","title":"Deciphering the Plasma Proteome of Type 2 Diabetes","abstract":"With an estimated prevalence of 463 million affected, type 2 diabetes represents a major challenge to health care systems worldwide. Analyzing the plasma proteomes of individuals with type 2 diabetes may illuminate hitherto unknown functional mechanisms underlying disease pathology. We assessed the associations between type 2 diabetes and >1,000 plasma proteins in the Cooperative Health Research in the Region of Augsburg (KORA) F4 cohort (n = 993, 110 cases), with subsequent replication in the third wave of the Nord-Trøndelag Health Study (HUNT3) cohort (n = 940, 149 cases). We computed logistic regression models adjusted for age, sex, BMI, smoking status, and hypertension. Additionally, we investigated associations with incident type 2 diabetes and performed two-sample bidirectional Mendelian randomization (MR) analysis to prioritize our results. Association analysis of prevalent type 2 diabetes revealed 24 replicated proteins, of which 8 are novel. Proteins showing association with incident type 2 diabetes were aminoacylase-1, growth hormone receptor, and insulin-like growth factor–binding protein 2. Aminoacylase-1 was associated with both prevalent and incident type 2 diabetes. MR analysis yielded nominally significant causal effects of type 2 diabetes on cathepsin Z and rennin, both known to have roles in the pathophysiological pathways of cardiovascular disease, and of sex hormone–binding globulin on type 2 diabetes. In conclusion, our high-throughput proteomics study replicated previously reported type 2 diabetes–protein associations and identified new candidate proteins possibly involved in the pathogenesis of type 2 diabetes.","journal":"Diabetes","year":2020,"id":60053,"datarank":2.0062470262883356,"base_score":4.174387269895637,"endowment":4.174387269895637,"self_citation_contribution":0.6261580904843456,"citation_network_contribution":1.38008893580399,"self_endowment_contribution":0.6261580904843456,"citer_contribution":1.38008893580399,"corpus_percentile":null,"corpus_rank":null,"citation_count":64,"citer_count":50,"citers_with_citation_signal":44,"citers_with_endowment":44,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.5243,"is_data_producer":true,"deposit_databanks":{"figshare":["10.2337/figshare.12896426"]},"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2020-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":316761,"name":"Christian Jonasson","orcid":"0000-0002-7694-6025","position":1,"is_corresponding":false},{"id":90142,"name":"Cornelia Huth","orcid":"0000-0003-2421-433X","position":2,"is_corresponding":false},{"id":316762,"name":"Rory Wilson","orcid":"0000-0001-6135-3764","position":3,"is_corresponding":false},{"id":2351,"name":"Christian Gieger","orcid":"0000-0001-6986-9554","position":4,"is_corresponding":false},{"id":318912,"name":"Pamela Matias","orcid":null,"position":5,"is_corresponding":false},{"id":2352,"name":"Harald Grallert","orcid":"0000-0002-6876-9655","position":6,"is_corresponding":false},{"id":89029,"name":"Johannes Graumann","orcid":"0000-0002-3015-5850","position":7,"is_corresponding":false},{"id":266984,"name":"Valérie Gailus‐Durner","orcid":"0000-0002-6076-0111","position":8,"is_corresponding":false},{"id":19621,"name":"Wolfgang Rathmann","orcid":"0000-0001-7804-1740","position":9,"is_corresponding":false},{"id":96908,"name":"Christine von Toerne","orcid":"0000-0002-4132-4322","position":10,"is_corresponding":false},{"id":25246,"name":"Stefanie M. Hauck","orcid":"0000-0002-1630-6827","position":11,"is_corresponding":false},{"id":54958,"name":"Wolfgang Köenig","orcid":"0000-0002-2064-9603","position":12,"is_corresponding":false},{"id":55717,"name":"Moritz F. Sinner","orcid":"0000-0002-6660-796X","position":13,"is_corresponding":false},{"id":68160,"name":"Tudor I. Oprea","orcid":"0000-0002-6195-6976","position":14,"is_corresponding":false},{"id":2350,"name":"Karsten Suhre","orcid":"0000-0001-9638-3912","position":15,"is_corresponding":false},{"id":19632,"name":"Barbara Thorand","orcid":"0000-0002-8416-6440","position":16,"is_corresponding":false},{"id":262547,"name":"Kristian Hveem","orcid":"0000-0001-8157-9744","position":17,"is_corresponding":false},{"id":2343,"name":"Annette Peters","orcid":"0000-0001-6645-0985","position":18,"is_corresponding":false},{"id":18662,"name":"Mélanie Waldenberger","orcid":"0000-0003-0583-5093","position":19,"is_corresponding":false},{"id":291143,"name":"Mohamed A. Elhadad","orcid":"0000-0002-6758-8369","position":0,"is_corresponding":true}],"reference_count":59,"raw_metadata":null,"created_at":"2026-07-18T21:08:47.852401Z","pmid":"32928870","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}