{"doi":"10.2310/7070.2001.20818","title":"Differential Vulnerability of Inner and Outer Hair Cell Systems to Chronic Mild Hypoxia and Glutamate Ototoxicity: Insights into the Cause of Auditory Neuropathy","abstract":null,"journal":"The Journal of Otolaryngology","year":2001,"id":676961,"datarank":0.5926865577872142,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"self_citation_contribution":0.5926865577872142,"citation_network_contribution":0.0,"self_endowment_contribution":0.5926865577872142,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":51,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1588806,"name":"Naoki Mori","orcid":null,"position":1,"is_corresponding":false},{"id":1768758,"name":"Richard J. Mount","orcid":null,"position":2,"is_corresponding":false},{"id":1768759,"name":"Robert V. Harrison","orcid":null,"position":3,"is_corresponding":false},{"id":1768757,"name":"Shoichi Sawada","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Differential Vulnerability of Inner and Outer Hair Cell Systems to Chronic Mild Hypoxia and Glutamate Ototoxicity: Insights into the Cause of Auditory Neuropathy","abstract":"OBJECTIVE: To describe the effects of long-term mild hypoxia and of glutamate poisoning on the functional properties of the cochlea. METHODS: Outer hair cell activity was monitored using otoacoustic emissions and cochlear microphonics, and inner hair cell/cochlear afferent function was measured using neural responses (cochlear action potentials or auditory brainstem responses [ABRs]). RESULTS: In contrast to the effects of acute anoxia, in which all aspects of cochlear function are simultaneously lost, mild, long-term hypoxia results in a clear differential effect on outer versus inner hair cell systems. During a 2-hour period of mild hypoxia, ABR amplitude and threshold deteriorate significantly, whereas outer hair cell function, as reflected by otoacoustic emissions, shows little or no change. A similar dissociation between inner and outer hair cell function is observed during instillation of glutamate (1-10 mM), where the cochlear microphonic and the otoacoustic emissions are unchanged, whereas cochlear action potential amplitudes are reduced. CONCLUSION: These studies demonstrate a difference in vulnerability of inner and outer hair cell systems. The inner hair cell/cochlear afferent system is vulnerable to long-term, mild hypoxia; this may be an etiologic factor in hearing loss of cochlear origin, particularly in high-risk birth infants with auditory neuropathy.","is_dataset_classified":null,"base_score":3.9512437185814275,"endowment":3.9512437185814275,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"11770952","pmcid":null,"openalex_id":"https://openalex.org/W1970698282","authors":[],"funders":[],"total_grants":0,"fwci":0.639,"citation_percentile":0.61976848,"influential_citations":0,"citation_trend":[{"year":2012,"count":2},{"year":2014,"count":3},{"year":2015,"count":2},{"year":2016,"count":5},{"year":2017,"count":2},{"year":2019,"count":3},{"year":2020,"count":1},{"year":2021,"count":4},{"year":2022,"count":5},{"year":2023,"count":1},{"year":2024,"count":1},{"year":2025,"count":1}],"oa_status":"closed","license":null,"oa_locations":[{"url":"https://doi.org/10.2310/7070.2001.20818","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/11770952","host_type":"repository"}],"fields_of_study":["Hearing, Cochlea, Tinnitus, Genetics","Neonatal and fetal brain pathology","Neuroscience of respiration and sleep","Animals","Cell Hypoxia","Chinchilla","Cochlear Microphonic Potentials","Glutamic Acid","Hair Cells, Auditory, Inner","Hair Cells, Auditory, Outer","Microscopy, Electron, Scanning","Otoacoustic Emissions, Spontaneous","Time Factors","Vestibulocochlear Nerve Diseases"],"mesh_terms":["Vestibulocochlear Nerve Diseases","Animals","Chinchilla","Cochlear Microphonic Potentials","Hair Cells, Auditory, Inner","Microscopy, Electron, Scanning","Time Factors","Cell Hypoxia","Otoacoustic Emissions, Spontaneous","Hair Cells, Auditory, Outer","Glutamic Acid"],"keywords":["Hair cell","Cochlea","Auditory neuropathy","Inner ear","Medicine","Audiology","Auditory brainstem response","Ototoxicity","Hypoxia (environmental)","Hearing loss","Glutamate receptor","Auditory system","Neuroscience","Anatomy","Internal medicine","Biology","Chemistry","Oxygen"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-17T03:25:06.530237Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}