{"doi":"10.2310/6650.2005.00402","title":"Breaking the Translational Barriers: The Value of Integrating Biomedical Informatics and Translational Research","abstract":"<jats:p>The conduct of translational health research has become a vital national enterprise. However, multiple barriers prevent the effective translation of basic science discoveries into clinical and community practice. New information technology (IT) applications could help address these barriers. Unfortunately, owing to a combination of organizational, technical, and social factors, neither physician-investigators and research staff nor their clinical and community counterparts have harnessed such applications. Recently, at the request of the Institute of Medicine's Clinical Research Roundtable, a qualitative study of these factors was conducted at several leading academic medical centers. We explore the current status of IT in the translational research domain, describe the qualitative results, and conclude with a proposed set of initiatives to further increase the integration of IT into translational research.</jats:p>","journal":"Journal of Investigative Medicine","year":2005,"id":13540,"datarank":4.713361627213303,"base_score":4.553876891600541,"endowment":4.553876891600541,"self_citation_contribution":0.6830815337400812,"citation_network_contribution":4.030280093473222,"self_endowment_contribution":0.6830815337400812,"citer_contribution":4.030280093473222,"corpus_percentile":null,"corpus_rank":null,"citation_count":94,"citer_count":53,"citers_with_citation_signal":44,"citers_with_endowment":44,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":110733,"name":"Stephen B. Johnson","orcid":null,"position":1,"is_corresponding":false},{"id":110734,"name":"Justin B. Starren","orcid":null,"position":2,"is_corresponding":false},{"id":110735,"name":"Hugh H. Tilson","orcid":null,"position":3,"is_corresponding":false},{"id":110701,"name":"David Dowdy","orcid":null,"position":4,"is_corresponding":false},{"id":110732,"name":"Philip R. O. Payne","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"base_score":4.553876891600541,"endowment":4.553876891600541,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"15974245","pmcid":null,"openalex_id":"https://openalex.org/W2049103437","authors":[],"funders":[],"total_grants":0,"fwci":6.1581,"citation_percentile":0.959957,"influential_citations":1,"citation_trend":[{"year":2012,"count":4},{"year":2013,"count":7},{"year":2014,"count":6},{"year":2015,"count":2},{"year":2016,"count":7},{"year":2017,"count":4},{"year":2018,"count":1},{"year":2019,"count":5},{"year":2020,"count":2},{"year":2021,"count":8},{"year":2022,"count":3},{"year":2023,"count":4},{"year":2024,"count":1}],"oa_status":"closed","license":"https://journals.sagepub.com/page/policies/text-and-data-mining-license","oa_locations":[{"url":"https://journals.sagepub.com/doi/pdf/10.2310/6650.2005.00402","host_type":"publisher"},{"url":"https://journals.sagepub.com/doi/full-xml/10.2310/6650.2005.00402","host_type":"publisher"},{"url":"https://doi.org/10.2310/6650.2005.00402","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/15974245","host_type":"repository"}],"fields_of_study":["Health and Medical Research Impacts","Genetics, Bioinformatics, and Biomedical Research","Biomedical Text Mining and Ontologies","Medicine","Computer Science","Biomedical Research","Humans","Internet","Medical Informatics","Research Support as Topic"],"mesh_terms":["Humans","Medical Informatics","Research Support as Topic","Internet","Biomedical Research"],"keywords":["Translational research","Translational research informatics","Translational science","Translational medicine","Informatics","Medical research","Health informatics","Qualitative research","Engineering ethics","Medicine","Value (mathematics)","Knowledge management","Political science","Health Administration Informatics","Computer science","Engineering","Nursing","Sociology","Public health","Pathology","Social science"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Partnerships for the goals"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-05-30T19:41:10.015684Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}