{"doi":"10.2298/sarh1106339m","title":"The role of hormonal ovarian ablation in adjuvant treatment of premenopausal breast cancer","abstract":"<jats:p>Introduction. Breast cancer is the most frequent malignant disease in women\n   with about 25% compared to all malignant tumours. Chemotherapy, antiestrogen\n   and ovarian ablation/ supression present effective adjuvant approach for\n   premenopausal women diagnosed with hormonal depended, operable breast cancer.\n   Objective. To evaluate benefits of combined chemo/hormonal therapy that is\n   undutiful, but optimal application has not yet been clearly determined.\n   Methods. Thirty-six women were divided into three therapy groups. The first\n   group (13 women) was treated with six cycles of adjuvant FAC chemotherapy\n   followed by regular check-ups; the second group (13 women) after six cycles\n   of adjuvant FAC chemotherapy continued treatment with a two-year application\n   of goserelin given by subcutaneous injections (FAC-Z); the third group (10\n   women), after six cycles of adjuvant FAC chemotherapy continued with once per\n   month application of gorselin for two years and a daily application of 20 mg\n   tamoxifen for five years (FAC-Z-T). The length of overall disease free period\n   and survival were analyzed in all three groups. Results. The benefit of LH-RH\n   analogues in premenopausal women with hormone-dependent breast cancer was\n   found to be low, and probably limited to smaller subgroups of patients,\n   possibly such as those with either both steroid receptors positive (ER and\n   PR) or those with an extremely high level of steroid receptors. In our paper,\n   analyses of such subgroups could not been performed due to a small sample of\n   patients. The effect of therapy is better in patients, who developed\n   amenorrhoea, regardless of the type of later hormonal therapy. Conclusion.\n   Ovarial ablation, whatever the method, should be probably applied as early as\n   possible within the treatment of early breast cancer, especially in patients\n   in whom chemotherapy induced amenorrhoea is not expected, i.e. in very young\n   female patients.</jats:p>","journal":"Srpski arhiv za celokupno lekarstvo","year":2011,"id":653311,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1704605,"name":"Zora Neskovic-Konstantinovic","orcid":null,"position":1,"is_corresponding":false},{"id":1704607,"name":"Natasa Stanisavljevic","orcid":null,"position":2,"is_corresponding":false},{"id":1704609,"name":"Vladimir Kovcin","orcid":null,"position":3,"is_corresponding":false},{"id":1704603,"name":"Zafir Murtezani","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"The role of hormonal ovarian ablation in adjuvant treatment of premenopausal breast cancer","abstract":"<jats:p>Introduction. Breast cancer is the most frequent malignant disease in women\n   with about 25% compared to all malignant tumours. Chemotherapy, antiestrogen\n   and ovarian ablation/ supression present effective adjuvant approach for\n   premenopausal women diagnosed with hormonal depended, operable breast cancer.\n   Objective. To evaluate benefits of combined chemo/hormonal therapy that is\n   undutiful, but optimal application has not yet been clearly determined.\n   Methods. Thirty-six women were divided into three therapy groups. The first\n   group (13 women) was treated with six cycles of adjuvant FAC chemotherapy\n   followed by regular check-ups; the second group (13 women) after six cycles\n   of adjuvant FAC chemotherapy continued treatment with a two-year application\n   of goserelin given by subcutaneous injections (FAC-Z); the third group (10\n   women), after six cycles of adjuvant FAC chemotherapy continued with once per\n   month application of gorselin for two years and a daily application of 20 mg\n   tamoxifen for five years (FAC-Z-T). The length of overall disease free period\n   and survival were analyzed in all three groups. Results. The benefit of LH-RH\n   analogues in premenopausal women with hormone-dependent breast cancer was\n   found to be low, and probably limited to smaller subgroups of patients,\n   possibly such as those with either both steroid receptors positive (ER and\n   PR) or those with an extremely high level of steroid receptors. In our paper,\n   analyses of such subgroups could not been performed due to a small sample of\n   patients. The effect of therapy is better in patients, who developed\n   amenorrhoea, regardless of the type of later hormonal therapy. Conclusion.\n   Ovarial ablation, whatever the method, should be probably applied as early as\n   possible within the treatment of early breast cancer, especially in patients\n   in whom chemotherapy induced amenorrhoea is not expected, i.e. in very young\n   female patients.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21858973","pmcid":null,"openalex_id":"https://openalex.org/W2020893557","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.09107021,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"http://www.doiserbia.nb.rs/ft.aspx?id=0370-81791106339M","host_type":"journal"},{"url":"http://www.doiserbia.nb.rs/ft.aspx?id=0370-81791106339M","host_type":"publisher"},{"url":"https://doi.org/10.2298/sarh1106339m","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/21858973","host_type":"repository"},{"url":"https://doaj.org/article/4f981bf7d1ba4c10a387a21f265595c8","host_type":"repository"},{"url":"http://doi.org/10.2298/SARH1106339M","host_type":"repository"}],"fields_of_study":["Breast Cancer Treatment Studies","Male Breast Health Studies","Breast Lesions and Carcinomas","Adult","Antineoplastic Agents, Hormonal","Antineoplastic Combined Chemotherapy Protocols","Breast Neoplasms","Chemotherapy, Adjuvant","Cyclophosphamide","Disease-Free Survival","Doxorubicin","Estrogen Antagonists","Female","Fluorouracil","Goserelin","Humans","Middle Aged","Premenopause","Survival Rate","Tamoxifen","CAF protocol"],"mesh_terms":["Adult","Antineoplastic Combined Chemotherapy Protocols","Breast Neoplasms","Cyclophosphamide","Doxorubicin","Estrogen Antagonists","Female","Fluorouracil","Humans","Middle Aged","Tamoxifen","Survival Rate","Chemotherapy, Adjuvant","Goserelin","Premenopause","Disease-Free Survival","Antineoplastic Agents, Hormonal"],"keywords":["Medicine","Tamoxifen","Goserelin","Antiestrogen","Hormonal therapy","Breast cancer","Chemotherapy","Adjuvant","Hormone","Oncology","Internal medicine","Cancer","Adjuvant therapy","Gynecology","Hormone therapy"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-10T20:45:21.920562Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}