{"doi":"10.22541/au.158775673.36819986","title":"Cholesterol and oxysterol sulfates: Physiological roles and analytical challenges","abstract":"<jats:p>Cholesterol (Chol) and oxysterol sulfates are important regulators of\nlipid metabolism, inflammation, cell apoptosis, and cell survival. Among\nthe sulfate-based lipids, cholesterol sulfate (CS) is the most studied\nlipid both quantitatively and functionally. Despite the importance, very\nfew studies have analysed and linked the actions of oxysterol sulfates\nto their physiological roles. Over expression of sulfotransferases\nconfirmed the formation of a range of oxysterol sulfates and their\nantagonistic effects on liver X receptors (LXRs). It is therefore\nimportant to understand how further changes to oxysterol/oxysterol\nsulfate homeostasis can contribute to LXR activity in the physiological\nmilieu. Here, we aim to bring together evidences for novel roles of\noxysterol sulfates, the available techniques and the challenges for\nanalysing them. Understanding the oxysterol/oxysterol sulfate levels and\ntheir physiological mechanisms could lead to new therapeutic targets for\nmetabolic diseases.</jats:p>","journal":null,"year":null,"id":595173,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1523915,"name":"Lorenzo Pontini","orcid":null,"position":1,"is_corresponding":false},{"id":1523917,"name":"Maura Marinozzi","orcid":"0000-0001-5994-9390","position":2,"is_corresponding":false},{"id":1523920,"name":"Lissette Sanchez-Aranguren","orcid":null,"position":3,"is_corresponding":false},{"id":1523921,"name":"Ana Reis","orcid":"0000-0002-4537-9902","position":4,"is_corresponding":false},{"id":1523923,"name":"Irundika Dias","orcid":null,"position":5,"is_corresponding":false},{"id":1523913,"name":"Lorena Diaz Sanchez","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Cholesterol and oxysterol sulfates: Physiological roles and analytical challenges","abstract":"<jats:p>Cholesterol (Chol) and oxysterol sulfates are important regulators of\nlipid metabolism, inflammation, cell apoptosis, and cell survival. Among\nthe sulfate-based lipids, cholesterol sulfate (CS) is the most studied\nlipid both quantitatively and functionally. Despite the importance, very\nfew studies have analysed and linked the actions of oxysterol sulfates\nto their physiological roles. Over expression of sulfotransferases\nconfirmed the formation of a range of oxysterol sulfates and their\nantagonistic effects on liver X receptors (LXRs). It is therefore\nimportant to understand how further changes to oxysterol/oxysterol\nsulfate homeostasis can contribute to LXR activity in the physiological\nmilieu. Here, we aim to bring together evidences for novel roles of\noxysterol sulfates, the available techniques and the challenges for\nanalysing them. Understanding the oxysterol/oxysterol sulfate levels and\ntheir physiological mechanisms could lead to new therapeutic targets for\nmetabolic diseases.</jats:p>","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"21097893","pmcid":null,"openalex_id":"https://openalex.org/W3049173200","authors":[],"funders":[],"total_grants":0,"fwci":null,"citation_percentile":null,"influential_citations":0,"citation_trend":[],"oa_status":"green","license":"cc-by","oa_locations":[{"url":"https://21docs.com/doi/pdf/10.22541/au.158775673.36819986","host_type":"repository"},{"url":"https://21docs.com/doi/pdf/10.22541/au.158775673.36819986","host_type":"repository"},{"url":"https://www.authorea.com/doi/pdf/10.22541/au.158775673.36819986","host_type":"publisher"},{"url":"https://doi.org/10.22541/au.158775673.36819986","host_type":"repository"}],"fields_of_study":["Cholesterol and Lipid Metabolism"],"mesh_terms":[],"keywords":["Oxysterol","Chemistry","Cholesterol","Biochemistry","Lipid metabolism","Metabolism","Cell biology","Biology"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Good health and well-being"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-27T16:49:23.443526Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}