{"doi":"10.22540/jfsf-10-218","title":"Frailty and Physical Activity: A Compositional Isotemporal Substitution Analysis from the All of Us Research Program","abstract":"Objectives: The objective of this study was to quantify the impact of shifting time away from sedentary behavior to physical activity on frailty in older adults. Methods: Participants from the All of Us Research Program with Fitbit data were included in the analysis. Fitbit data was used to measure time spent in sleep, sedentary behavior, light-intensity physical activity, and moderate-to-vigorous physical activity. Frailty was assessed using a 33-item frailty index. A compositional isotemporal substitution model was created to assess the estimated effects of substituting 30 minutes of sedentary behavior with an equal amount of time in physical activity on frailty. Results: Reductions in frailty index were seen by shifting 30 minutes from sedentary behavior to light activity (-0.003 [95% CI: -0.004, -0.002]) and moderate-to-vigorous activity (-0.016 [-0.017, -0.014]). Lower odds of frailty were also seen from shifting time from sedentary behavior to light activity or moderate-to-vigorous activity. Associations between physical activity and frailty were generally more pronounced in those participants who were frail or pre-frail than in those who were robust. Conclusions: Shifting time from sedentary behavior to physical activity is associated with lower odds of frailty, and shifting time to higher intensity activities may have a greater benefit to frailty.","journal":"Journal of Frailty Sarcopenia and Falls","year":2025,"id":549071,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":1,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.741,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2025-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":498774,"name":"Lisa Cadmus‐Bertram","orcid":"0000-0003-4835-2817","position":1,"is_corresponding":false},{"id":1443232,"name":"Amy Cochran","orcid":null,"position":2,"is_corresponding":false},{"id":326318,"name":"Kristen A. Pickett","orcid":"0000-0002-4889-6817","position":3,"is_corresponding":false},{"id":270996,"name":"Sandesh Parajuli","orcid":"0000-0003-1667-7465","position":4,"is_corresponding":false},{"id":407697,"name":"Brad C. Astor","orcid":"0000-0002-0876-0069","position":5,"is_corresponding":false},{"id":1065612,"name":"Christian Schmidt","orcid":"0000-0002-9333-1620","position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T02:54:03.053965Z","pmid":"41341115","pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}