{"doi":"10.22489/cinc.2023.354","title":"Interdependence in the Cardiorespiratory Network of Preterm Infants with Pulmonary Hypertension Using Mutual Information Analysis","abstract":"Aim: Immature development predisposes preterm infants to cardiorespiratory morbidities such as pulmonary hypertension (PH) and bronchopulmonary dysplasia (BPD). This study investigated interdependence in the cardiorespiratory network and identified differences exhibited by infants with BPD alone and those with the added complication of PH. Methods: Heart rate (HR), respiratory rate (RR) and oxygen saturation (SpO2) from 17 infants with BPD alone (NoPH group) and 21 infants with BPD and PH (PH group) were analyzed using mutual information (MI). MI over varying time delays between pairs of signals were estimated and the maximum value, mxMI, if significant, was extracted and compared between groups.Results: Interdependence differed based on condition and coupling signals.Within groups, MI(HR-SpO2) was strongest while HR-RR had the smallest magnitude dependence.HR-SpO2 coupling in the PH group was higher than in the NoPH group (p<0.001).The shortest mean delay occurred in the HR-RR interaction.Conclusion: Cardiorespiratory interaction strengths were altered in preterm infants with both BPD and PH.Information transfer between cardiorespiratory network components in preterm infants may hence provide insights to mechanisms of disease progression and needs to be explored further.","journal":"Computing in cardiology","year":2023,"id":415505,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":0.9516,"is_data_producer":false,"deposit_databanks":null,"is_oa":true,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":"2023-01-01","fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":552044,"name":"Premananda Indic","orcid":"0000-0001-8366-0044","position":1,"is_corresponding":false},{"id":455513,"name":"Samuel J. Gentle","orcid":"0000-0003-0238-6472","position":2,"is_corresponding":false},{"id":409094,"name":"Namasivayam Ambalavanan","orcid":"0000-0003-0731-9092","position":3,"is_corresponding":false},{"id":1007857,"name":"Pravitha Ramanand","orcid":null,"position":0,"is_corresponding":true}],"reference_count":0,"raw_metadata":null,"created_at":"2026-07-19T01:22:12.933438Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}