{"doi":"10.22246/jikm.2020.41.4.599","title":"Effects of a Hwanggi-tang Ethanol Extract on Glucose Uptake and Metabolism in Murine Myotubes","abstract":null,"journal":"The Journal of Internal Korean Medicine","year":2020,"id":634187,"datarank":0.0,"base_score":0.0,"endowment":0.0,"self_citation_contribution":0.0,"citation_network_contribution":0.0,"self_endowment_contribution":0.0,"citer_contribution":0.0,"corpus_percentile":null,"corpus_rank":null,"citation_count":0,"citer_count":0,"citers_with_citation_signal":0,"citers_with_endowment":0,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1644670,"name":"Sun-ho Shin","orcid":null,"position":1,"is_corresponding":false},{"id":1644671,"name":"Yong-jeen Shin","orcid":null,"position":2,"is_corresponding":false},{"id":1644669,"name":"Chul-yong Jang","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Effects of a Hwanggi-tang Ethanol Extract on Glucose Uptake and Metabolism in Murine Myotubes","abstract":"Objectives The aim of this study was to evaluate the effects of Hwanggi-tang on glucose digestion, uptake, and metabolism in murine C2C12 myotubes. Methods Hwanggi-tang was prepared according to the Dong-ui-bo-gam (≪東醫寶鑑≫) prescription by 70% ethanol extraction. The effect on glucose digestion was examined by determining the inhibitory effect of Hwanggi-tang on α-glucosidase activity. We also compared and verified the gene and protein expression of genes related to glucose uptake in C2C12 myotubes treated with Hwanggi-tang or insulin. Glucose metabolism was assessed by the expression levels of associated enzymes. Results Hwanggi-tang caused a dose-dependent inhibition of α-glucosidase activity, induced glucose uptake by activation of the PI3K/Akt/mTOR pathway in the insulin signaling pathway, and promoted glucose oxidation and β-oxidation. Conclusions Hwanggi-tang exerts an anti-diabetic effect on murine myotubes by inhibiting glucose digestion and inducing glucose uptake and consumption. Keywords: carbohydrate metabolism, diabetes mellitus, herbal medicine, skeletal muscle fiber","is_dataset_classified":null,"base_score":0.0,"endowment":0.0,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"19767382","pmcid":null,"openalex_id":"https://openalex.org/W3094440128","authors":[],"funders":[],"total_grants":0,"fwci":0.0,"citation_percentile":0.10145735,"influential_citations":0,"citation_trend":[],"oa_status":"gold","license":"cc-by-nc","oa_locations":[{"url":"https://www.jikm.or.kr/upload/pdf/jikm-41-4-599.pdf","host_type":"journal"},{"url":"https://www.jikm.or.kr/upload/pdf/jikm-41-4-599.pdf","host_type":"publisher"},{"url":"http://jikm.or.kr/upload/pdf/jikm-41-4-599.pdf","host_type":"publisher"},{"url":"http://jikm.or.kr/journal/view.php?doi=10.22246/jikm.2020.41.4.599","host_type":"publisher"},{"url":"https://doi.org/10.22246/jikm.2020.41.4.599","host_type":"journal"}],"fields_of_study":["Metabolism, Diabetes, and Cancer","Cancer, Hypoxia, and Metabolism","Biochemical Acid Research Studies"],"mesh_terms":[],"keywords":["Glucose uptake","Carbohydrate metabolism","Internal medicine","Metabolism","Endocrinology","Myogenesis","Insulin","Digestion (alchemy)","Medicine","PI3K/AKT/mTOR pathway","Diabetes mellitus","Protein kinase B","Biochemistry","Skeletal muscle","Chemistry","Signal transduction"],"sdg_mappings":[{"sdg_number":0,"sdg_label":"Zero hunger"}],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-08-06T13:17:43.616737Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}