{"doi":"10.2222/jsv.55.267","title":"Antiviral defense by APOBEC3 Family Proteins","abstract":null,"journal":"Uirusu","year":2005,"id":604794,"datarank":0.604742972949354,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"self_citation_contribution":0.37273599746820013,"citation_network_contribution":0.23200697548115387,"self_endowment_contribution":0.37273599746820013,"citer_contribution":0.23200697548115387,"corpus_percentile":null,"corpus_rank":null,"citation_count":11,"citer_count":11,"citers_with_citation_signal":9,"citers_with_endowment":9,"datacite_reuse_total":0,"is_dataset":false,"is_dataset_confidence":null,"is_data_producer":false,"deposit_databanks":null,"is_oa":false,"file_count":0,"downloads":0,"has_version_chain":false,"published_date":null,"fair_score":null,"fair_percentile":null,"algorithm_id":"datarank_citation_only_1hop_v6","ranking_scope":"data_only","authors":[{"id":1551849,"name":"Akifumi TAKAORI","orcid":null,"position":0,"is_corresponding":false}],"reference_count":0,"raw_metadata":{"has_enrichment":true,"resolved":true,"title":"Antiviral defense by APOBEC3 Family Proteins","abstract":"APOBEC3G is a potent antiretroviral factor, which belongs to the APOBEC superfamily of cytidine deaminases. It deaminates cytidine to uridine in nascent minus-strand viral DNA, inducing G-to-A hypermutation in the plus-strand viral DNA. HIV-1 Vif protein overcomes the antiviral activity of APOBEC3G by targeting it for ubiquitin-dependent degradation. Recent accumulating evidences that other members of APOBEC proteins also show antiviral activity on a wide variety of viruses suggest that APOBEC family proteins play a crucial role in an antiviral defense as an innate immunity. Here, we review recent progress in research on APOBEC3 proteins.","is_dataset_classified":null,"base_score":2.4849066497880004,"endowment":2.4849066497880004,"datacite_reuse_total":0,"file_count":0,"downloads":0,"views":0,"has_version_chain":false,"is_dataset":false,"is_oa":false,"pmid":"16557012","pmcid":null,"openalex_id":"https://openalex.org/W2055611761","authors":[],"funders":[],"total_grants":0,"fwci":0.1004,"citation_percentile":0.37408251,"influential_citations":0,"citation_trend":[{"year":2015,"count":1},{"year":2016,"count":3},{"year":2017,"count":1},{"year":2018,"count":1},{"year":2022,"count":2},{"year":2025,"count":1}],"oa_status":"bronze","license":null,"oa_locations":[{"url":"https://www.jstage.jst.go.jp/article/jsv/55/2/55_2_267/_pdf","host_type":"journal"},{"url":"https://www.jstage.jst.go.jp/article/jsv/55/2/55_2_267/_pdf","host_type":"publisher"},{"url":"https://doi.org/10.2222/jsv.55.267","host_type":"journal"},{"url":"https://pubmed.ncbi.nlm.nih.gov/16557012","host_type":"repository"}],"fields_of_study":["HIV Research and Treatment","Cytomegalovirus and herpesvirus research","interferon and immune responses"],"mesh_terms":["APOBEC Deaminases","Animals","Cytidine Deaminase","DNA, Viral","Multigene Family","Humans","Immunity, Innate","HIV-1","HIV Infections","Gene Products, vif","Anti-HIV Agents","Cytosine Deaminase","vif Gene Products, Human Immunodeficiency Virus"],"keywords":["APOBEC3G","APOBEC","Cytidine deaminase","Somatic hypermutation","Cytidine","Biology","Innate immune system","DNA","Virology","Genetics","Biochemistry","Genome","Antibody","Gene","Enzyme","Immune system"],"sdg_mappings":[],"linked_datasets":[],"clinical_trials":[],"software_tools":[],"database_accessions":[],"source":"live","citation_network_status":"fetched"},"created_at":"2026-07-30T00:56:25.033118Z","pmid":null,"pmcid":null,"fwci":null,"citation_percentile":null,"influential_citations":0,"oa_status":null,"license":null,"views":0,"total_file_size_bytes":0,"version_count":0,"fair_f":null,"fair_a":null,"fair_i":null,"fair_r":null,"fair_zscore":null,"fair_rationale":null,"fair_model":null,"fair_agent_version":null,"fair_fulltext_source":null,"fair_has_llm":null,"fair_computed_at":null,"clinical_trials":[],"software_tools":[],"db_accessions":[],"linked_datasets":[],"topics":[]}